Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) ar...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Hindawi Ltd
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/58721 |
| _version_ | 1848760322491416576 |
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| author | Deka, N. Bajare, S. Anthony, J. Nair, A. Damre, A. Patel, Dharmeshkumar B-Rao, C. Sivaramakrishnan, H. Mutt, S. Wilankar, C. Marita, R. |
| author_facet | Deka, N. Bajare, S. Anthony, J. Nair, A. Damre, A. Patel, Dharmeshkumar B-Rao, C. Sivaramakrishnan, H. Mutt, S. Wilankar, C. Marita, R. |
| author_sort | Deka, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance. |
| first_indexed | 2025-11-14T10:13:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-58721 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:13:56Z |
| publishDate | 2013 |
| publisher | Hindawi Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-587212018-05-01T05:51:13Z Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome Deka, N. Bajare, S. Anthony, J. Nair, A. Damre, A. Patel, Dharmeshkumar B-Rao, C. Sivaramakrishnan, H. Mutt, S. Wilankar, C. Marita, R. Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance. 2013 Journal Article http://hdl.handle.net/20.500.11937/58721 10.1155/2013/201580 http://creativecommons.org/licenses/by/3.0/ Hindawi Ltd fulltext |
| spellingShingle | Deka, N. Bajare, S. Anthony, J. Nair, A. Damre, A. Patel, Dharmeshkumar B-Rao, C. Sivaramakrishnan, H. Mutt, S. Wilankar, C. Marita, R. Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome |
| title | Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome |
| title_full | Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome |
| title_fullStr | Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome |
| title_full_unstemmed | Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome |
| title_short | Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome |
| title_sort | synthesis of n-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide derivatives for the treatment of metabolic syndrome |
| url | http://hdl.handle.net/20.500.11937/58721 |