Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules
© 2017 Elsevier B.V. Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory mo...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/58583 |
| _version_ | 1848760296880996352 |
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| author | Gardner, J. Mamotte, Cyril Jackaman, Connie Nelson, Delia |
| author_facet | Gardner, J. Mamotte, Cyril Jackaman, Connie Nelson, Delia |
| author_sort | Gardner, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Elsevier B.V. Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients. |
| first_indexed | 2025-11-14T10:13:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-58583 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:13:32Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-585832017-11-24T05:45:57Z Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules Gardner, J. Mamotte, Cyril Jackaman, Connie Nelson, Delia © 2017 Elsevier B.V. Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients. 2017 Journal Article http://hdl.handle.net/20.500.11937/58583 10.1016/j.arr.2017.07.002 restricted |
| spellingShingle | Gardner, J. Mamotte, Cyril Jackaman, Connie Nelson, Delia Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules |
| title | Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules |
| title_full | Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules |
| title_fullStr | Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules |
| title_full_unstemmed | Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules |
| title_short | Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules |
| title_sort | modulation of dendritic cell and t cell cross-talk during aging: the potential role of checkpoint inhibitory molecules |
| url | http://hdl.handle.net/20.500.11937/58583 |