A review of the importance of immune responses in luminal B breast cancer
© 2017 Taylor & Francis Group, LLC. Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Landes Bioscience
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/58478 |
| _version_ | 1848760270627799040 |
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| author | Nelson, Delia Clark, B. Munyard, K. Williams, V. Groth, David Gill, J. Preston, H. Chan, A. |
| author_facet | Nelson, Delia Clark, B. Munyard, K. Williams, V. Groth, David Gill, J. Preston, H. Chan, A. |
| author_sort | Nelson, Delia |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Taylor & Francis Group, LLC. Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies. |
| first_indexed | 2025-11-14T10:13:07Z |
| format | Journal Article |
| id | curtin-20.500.11937-58478 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:13:07Z |
| publishDate | 2017 |
| publisher | Landes Bioscience |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-584782018-03-29T09:09:01Z A review of the importance of immune responses in luminal B breast cancer Nelson, Delia Clark, B. Munyard, K. Williams, V. Groth, David Gill, J. Preston, H. Chan, A. © 2017 Taylor & Francis Group, LLC. Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies. 2017 Journal Article http://hdl.handle.net/20.500.11937/58478 10.1080/2162402X.2017.1282590 Landes Bioscience restricted |
| spellingShingle | Nelson, Delia Clark, B. Munyard, K. Williams, V. Groth, David Gill, J. Preston, H. Chan, A. A review of the importance of immune responses in luminal B breast cancer |
| title | A review of the importance of immune responses in luminal B breast cancer |
| title_full | A review of the importance of immune responses in luminal B breast cancer |
| title_fullStr | A review of the importance of immune responses in luminal B breast cancer |
| title_full_unstemmed | A review of the importance of immune responses in luminal B breast cancer |
| title_short | A review of the importance of immune responses in luminal B breast cancer |
| title_sort | review of the importance of immune responses in luminal b breast cancer |
| url | http://hdl.handle.net/20.500.11937/58478 |