Optimisation modelling of cancer growth
Several computational models have been developed in the litera- ture to describe the dynamics of the cell-cycle for the mammalian cell, in par- ticular for cancer cells, using both traditional and new techniques and yielding some positive results. In this paper, we discuss how to optimise model para...
| Main Authors: | , , |
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| Format: | Conference Paper |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/58449 |
| Summary: | Several computational models have been developed in the litera- ture to describe the dynamics of the cell-cycle for the mammalian cell, in par- ticular for cancer cells, using both traditional and new techniques and yielding some positive results. In this paper, we discuss how to optimise model param- eters for these types of models and how this can serve to enhance numerical results. We pose the model parameter selection problem as an optimal param- eter selection problem on both a normal cell and cancer cell cycle of growth. Various possible objectives are discussed and we illustrate the process with some numerical results. |
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