Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis
Aim: Short-term exercise training may induce metabolic and performance adaptations before any changes in mitochondrial enzyme potential. However, there has not been a study that has directly assessed changes in mitochondrial oxidative capacity or metabolic control as a consequence of such training i...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/58360 |
| _version_ | 1848760240397352960 |
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| author | Layec, G. Haseler, Luke Hoff, J. Hart, C. Liu, X. Le Fur, Y. Jeong, E. Richardson, R. |
| author_facet | Layec, G. Haseler, Luke Hoff, J. Hart, C. Liu, X. Le Fur, Y. Jeong, E. Richardson, R. |
| author_sort | Layec, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Aim: Short-term exercise training may induce metabolic and performance adaptations before any changes in mitochondrial enzyme potential. However, there has not been a study that has directly assessed changes in mitochondrial oxidative capacity or metabolic control as a consequence of such training in vivo. Therefore, we used 31 P-magnetic resonance spectroscopy ( 31 P-MRS) to examine the effect of short-term plantar flexion exercise training on phosphocreatine (PCr) recovery kinetics and the control of respiration rate. Method: To this aim, we investigated 12 healthy men, experienced with this exercise modality (TRA), and 7 time-control subjects (TC). Results: After 5 days of training, maximum work rate during incremental plantar flexion exercise was significantly improved (P < 0.01). During the recovery period, the maximal rate of oxidative adenosine triphosphate synthesis (PRE: 28 ± 13 mm min -1 ; POST: 26 ± 15 mm min -1 ) and the PCr recovery time constant (PRE: 31 ± 19 s; POST: 29 ± 16) were not significantly altered. In contrast, the Hill coefficient (n H ) describing the co-operativity between respiration rate and ADP was significantly increased in TRA (PRE: n H = 2.7 ± 1.4; POST: n H = 3.4 ± 1.9, P < 0.05). Meanwhile, there were no systematic variations in any of these variables in TC. Conclusion: This study reveals that 5 days of training induces rapid adaptation in the allosteric control of respiration rate by ADP before any substantial improvement in muscle oxidative capacity occurs. © 2013 Scandinavian Physiological Society. |
| first_indexed | 2025-11-14T10:12:38Z |
| format | Journal Article |
| id | curtin-20.500.11937-58360 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:12:38Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-583602018-03-29T09:08:39Z Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis Layec, G. Haseler, Luke Hoff, J. Hart, C. Liu, X. Le Fur, Y. Jeong, E. Richardson, R. Aim: Short-term exercise training may induce metabolic and performance adaptations before any changes in mitochondrial enzyme potential. However, there has not been a study that has directly assessed changes in mitochondrial oxidative capacity or metabolic control as a consequence of such training in vivo. Therefore, we used 31 P-magnetic resonance spectroscopy ( 31 P-MRS) to examine the effect of short-term plantar flexion exercise training on phosphocreatine (PCr) recovery kinetics and the control of respiration rate. Method: To this aim, we investigated 12 healthy men, experienced with this exercise modality (TRA), and 7 time-control subjects (TC). Results: After 5 days of training, maximum work rate during incremental plantar flexion exercise was significantly improved (P < 0.01). During the recovery period, the maximal rate of oxidative adenosine triphosphate synthesis (PRE: 28 ± 13 mm min -1 ; POST: 26 ± 15 mm min -1 ) and the PCr recovery time constant (PRE: 31 ± 19 s; POST: 29 ± 16) were not significantly altered. In contrast, the Hill coefficient (n H ) describing the co-operativity between respiration rate and ADP was significantly increased in TRA (PRE: n H = 2.7 ± 1.4; POST: n H = 3.4 ± 1.9, P < 0.05). Meanwhile, there were no systematic variations in any of these variables in TC. Conclusion: This study reveals that 5 days of training induces rapid adaptation in the allosteric control of respiration rate by ADP before any substantial improvement in muscle oxidative capacity occurs. © 2013 Scandinavian Physiological Society. 2013 Journal Article http://hdl.handle.net/20.500.11937/58360 10.1111/apha.12103 restricted |
| spellingShingle | Layec, G. Haseler, Luke Hoff, J. Hart, C. Liu, X. Le Fur, Y. Jeong, E. Richardson, R. Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis |
| title | Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis |
| title_full | Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis |
| title_fullStr | Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis |
| title_full_unstemmed | Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis |
| title_short | Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis |
| title_sort | short-term training alters the control of mitochondrial respiration rate before maximal oxidative atp synthesis |
| url | http://hdl.handle.net/20.500.11937/58360 |