Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection
Objectives: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection. Design: Cross-sectional study in antiretroviral therapy (ART)-naive (n=23) and ART-treated (n=27) HIV pa...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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2011
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| Online Access: | http://hdl.handle.net/20.500.11937/5816 |
| _version_ | 1848744901796167680 |
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| author | Lim, A. Amini, A. D'Orsogna, L. Rajasuriar, R. Kramski, M. Lewin, S. Purcell, D. Price, Patricia French, M. |
| author_facet | Lim, A. Amini, A. D'Orsogna, L. Rajasuriar, R. Kramski, M. Lewin, S. Purcell, D. Price, Patricia French, M. |
| author_sort | Lim, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection. Design: Cross-sectional study in antiretroviral therapy (ART)-naive (n=23) and ART-treated (n=27) HIV patients. Methods: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma. Results: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P=0.03 and 0.006, respectively), serum levels of IgA anti-LPS correlated with total IgA (P<0.0001) and levels of IgG anti-LPS correlated with IgM memory B-cell counts (P=0.025). In ART-treated patients, plasma LPS levels were not related to levels of LPS antibodies, but were related to CD4 T-cell and switched memory B-cell counts. There were no correlations with plasma levels of 16S rDNA. Conclusion: Plasma LPS levels were associated with antibody and possibly B-cell responses to LPS in ART-naive HIV patients, whereas they were associated with the degree of immune reconstitution in ART-treated patients. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| first_indexed | 2025-11-14T06:08:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-5816 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:08:50Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-58162017-09-13T14:43:27Z Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection Lim, A. Amini, A. D'Orsogna, L. Rajasuriar, R. Kramski, M. Lewin, S. Purcell, D. Price, Patricia French, M. Objectives: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection. Design: Cross-sectional study in antiretroviral therapy (ART)-naive (n=23) and ART-treated (n=27) HIV patients. Methods: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma. Results: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P=0.03 and 0.006, respectively), serum levels of IgA anti-LPS correlated with total IgA (P<0.0001) and levels of IgG anti-LPS correlated with IgM memory B-cell counts (P=0.025). In ART-treated patients, plasma LPS levels were not related to levels of LPS antibodies, but were related to CD4 T-cell and switched memory B-cell counts. There were no correlations with plasma levels of 16S rDNA. Conclusion: Plasma LPS levels were associated with antibody and possibly B-cell responses to LPS in ART-naive HIV patients, whereas they were associated with the degree of immune reconstitution in ART-treated patients. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. 2011 Journal Article http://hdl.handle.net/20.500.11937/5816 10.1097/QAD.0b013e328348a789 unknown |
| spellingShingle | Lim, A. Amini, A. D'Orsogna, L. Rajasuriar, R. Kramski, M. Lewin, S. Purcell, D. Price, Patricia French, M. Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection |
| title | Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection |
| title_full | Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection |
| title_fullStr | Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection |
| title_full_unstemmed | Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection |
| title_short | Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection |
| title_sort | antibody and b-cell responses may control circulating lipopolysaccharide in patients with hiv infection |
| url | http://hdl.handle.net/20.500.11937/5816 |