Metal organic frameworks as a drug delivery system for flurbiprofen
Background: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. Purpose: Flurbiprofen (FBP), a nonsteroi...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Dove Medical Press Ltd.
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/57977 |
| _version_ | 1848760146712330240 |
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| author | Al Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin |
| author_facet | Al Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin |
| author_sort | Al Haydar, Muder |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. Purpose: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employ ed for FBP delivery. Patients and methods: A sample of 50 mg of each MOF was mixed and stirred for 24 h with 10 mL of 5 mg FBP in acetonitrile (40%) in a sealed container. The supernatant of the mixture after centrifuging was analyzed by high-performance liquid chromatography to determine the loaded quantity of FBP on the MOF. The overnight-dried solid material after centrifuging the mixture was analyzed for loading percent using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance, and FBP release profile. Results: The loading values of FBP were achieved at 10.0%±1%, 20%±0.8%, 37%±2.3%, and 46%±3.1% on Ca-MOF, Fe-MIL-53, Fe-MIL-101, and Fe-MIL-100, respectively. The FBP release profiles were investigated in a phosphate buffer solution at pH 7.4. The total release of the FBP after 2 days was obtained at 72.9, 75.2, 78.3, and 90.3% for Ca-MOF, Fe-MIL-100, Fe-MIL-53, and Fe-MIL-101, respectively. Conclusion: The MOFs are shown to be a promising drug delivery option for FBP with a significant loading percent and relatively prolonged drug release. © 2017 AL Haydar et al. |
| first_indexed | 2025-11-14T10:11:09Z |
| format | Journal Article |
| id | curtin-20.500.11937-57977 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:11:09Z |
| publishDate | 2017 |
| publisher | Dove Medical Press Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-579772018-01-24T04:11:24Z Metal organic frameworks as a drug delivery system for flurbiprofen Al Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin Background: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. Purpose: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employ ed for FBP delivery. Patients and methods: A sample of 50 mg of each MOF was mixed and stirred for 24 h with 10 mL of 5 mg FBP in acetonitrile (40%) in a sealed container. The supernatant of the mixture after centrifuging was analyzed by high-performance liquid chromatography to determine the loaded quantity of FBP on the MOF. The overnight-dried solid material after centrifuging the mixture was analyzed for loading percent using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance, and FBP release profile. Results: The loading values of FBP were achieved at 10.0%±1%, 20%±0.8%, 37%±2.3%, and 46%±3.1% on Ca-MOF, Fe-MIL-53, Fe-MIL-101, and Fe-MIL-100, respectively. The FBP release profiles were investigated in a phosphate buffer solution at pH 7.4. The total release of the FBP after 2 days was obtained at 72.9, 75.2, 78.3, and 90.3% for Ca-MOF, Fe-MIL-100, Fe-MIL-53, and Fe-MIL-101, respectively. Conclusion: The MOFs are shown to be a promising drug delivery option for FBP with a significant loading percent and relatively prolonged drug release. © 2017 AL Haydar et al. 2017 Journal Article http://hdl.handle.net/20.500.11937/57977 10.2147/DDDT.S145716 https://creativecommons.org/licenses/by-nc/3.0/ Dove Medical Press Ltd. fulltext |
| spellingShingle | Al Haydar, Muder Abid, Hussein Rasool Sunderland, Bruce Wang, Shaobin Metal organic frameworks as a drug delivery system for flurbiprofen |
| title | Metal organic frameworks as a drug delivery system for flurbiprofen |
| title_full | Metal organic frameworks as a drug delivery system for flurbiprofen |
| title_fullStr | Metal organic frameworks as a drug delivery system for flurbiprofen |
| title_full_unstemmed | Metal organic frameworks as a drug delivery system for flurbiprofen |
| title_short | Metal organic frameworks as a drug delivery system for flurbiprofen |
| title_sort | metal organic frameworks as a drug delivery system for flurbiprofen |
| url | http://hdl.handle.net/20.500.11937/57977 |