The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV
Renal transplant recipients (RTR) display high burdens of cytomegalovirus (CMV) and accelerated cardiovascular change. NK cells can control CMV and may contribute to vascular pathologies. Polymorphisms in genes encoding the inhibitory receptor LILRB1 and its ligand HLA-G, and the activating receptor...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Inc.
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/57802 |
| _version_ | 1848760102191890432 |
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| author | Waters, Shelley Lee, Silvia Affandi, Jacquita Irish, A. Price, Patricia |
| author_facet | Waters, Shelley Lee, Silvia Affandi, Jacquita Irish, A. Price, Patricia |
| author_sort | Waters, Shelley |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Renal transplant recipients (RTR) display high burdens of cytomegalovirus (CMV) and accelerated cardiovascular change. NK cells can control CMV and may contribute to vascular pathologies. Polymorphisms in genes encoding the inhibitory receptor LILRB1 and its ligand HLA-G, and the activating receptor NKG2C may illuminate the role of NK cells in vascular health and CMV immunity.We assessed 81 healthy adults and 82 RTR > 2years after transplantation. RTR had higher humoral and T-cell responses to CMV, and impaired vascular health. A 14bp indel in HLA-G associated with increased flow-mediated dilatation of the brachial artery. The T allele of LILRB1 rs1061680 associated with increased carotid intimal media thickness (cIMT) in RTR and controls. A 16kb deletion encompassing the NKG2C gene associated with lower cIMT values and higher humoral and T-cell responses to CMV. Hence all polymorphisms tested had small but discernable effects on vascular health. The NKG2C deletion may act via CMV. |
| first_indexed | 2025-11-14T10:10:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-57802 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:10:26Z |
| publishDate | 2017 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-578022018-10-16T05:56:23Z The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV Waters, Shelley Lee, Silvia Affandi, Jacquita Irish, A. Price, Patricia Renal transplant recipients (RTR) display high burdens of cytomegalovirus (CMV) and accelerated cardiovascular change. NK cells can control CMV and may contribute to vascular pathologies. Polymorphisms in genes encoding the inhibitory receptor LILRB1 and its ligand HLA-G, and the activating receptor NKG2C may illuminate the role of NK cells in vascular health and CMV immunity.We assessed 81 healthy adults and 82 RTR > 2years after transplantation. RTR had higher humoral and T-cell responses to CMV, and impaired vascular health. A 14bp indel in HLA-G associated with increased flow-mediated dilatation of the brachial artery. The T allele of LILRB1 rs1061680 associated with increased carotid intimal media thickness (cIMT) in RTR and controls. A 16kb deletion encompassing the NKG2C gene associated with lower cIMT values and higher humoral and T-cell responses to CMV. Hence all polymorphisms tested had small but discernable effects on vascular health. The NKG2C deletion may act via CMV. 2017 Journal Article http://hdl.handle.net/20.500.11937/57802 10.1016/j.humimm.2017.10.003 Elsevier Inc. fulltext |
| spellingShingle | Waters, Shelley Lee, Silvia Affandi, Jacquita Irish, A. Price, Patricia The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV |
| title | The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV |
| title_full | The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV |
| title_fullStr | The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV |
| title_full_unstemmed | The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV |
| title_short | The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMV |
| title_sort | effect of genetic variants affecting nk cell function on cardiovascular health and the burden of cmv |
| url | http://hdl.handle.net/20.500.11937/57802 |