The applied biochemistry of PEDF and implications for tissue homeostasis
Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF bioc...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Informa Healthcare
2010
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| Online Access: | http://informahealthcare.com/journal/grf http://hdl.handle.net/20.500.11937/5775 |
| _version_ | 1848744890871054336 |
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| author | Broadhead, M. Becerra, S. Choong, P. Dass, Crispin |
| author_facet | Broadhead, M. Becerra, S. Choong, P. Dass, Crispin |
| author_sort | Broadhead, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and-tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application. |
| first_indexed | 2025-11-14T06:08:39Z |
| format | Journal Article |
| id | curtin-20.500.11937-5775 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:08:39Z |
| publishDate | 2010 |
| publisher | Informa Healthcare |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-57752018-03-29T09:05:22Z The applied biochemistry of PEDF and implications for tissue homeostasis Broadhead, M. Becerra, S. Choong, P. Dass, Crispin Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and-tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application. 2010 Journal Article http://hdl.handle.net/20.500.11937/5775 10.3109/08977191003604513 http://informahealthcare.com/journal/grf Informa Healthcare restricted |
| spellingShingle | Broadhead, M. Becerra, S. Choong, P. Dass, Crispin The applied biochemistry of PEDF and implications for tissue homeostasis |
| title | The applied biochemistry of PEDF and implications for tissue homeostasis |
| title_full | The applied biochemistry of PEDF and implications for tissue homeostasis |
| title_fullStr | The applied biochemistry of PEDF and implications for tissue homeostasis |
| title_full_unstemmed | The applied biochemistry of PEDF and implications for tissue homeostasis |
| title_short | The applied biochemistry of PEDF and implications for tissue homeostasis |
| title_sort | applied biochemistry of pedf and implications for tissue homeostasis |
| url | http://informahealthcare.com/journal/grf http://hdl.handle.net/20.500.11937/5775 |