Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells
© 2017 2017 Future Science Ltd. Aim: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due to its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed to examine antidiabetic effec...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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2017
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| Online Access: | http://hdl.handle.net/20.500.11937/57300 |
| _version_ | 1848760047046230016 |
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| author | Mooranian, A. Negrulj, R. Takechi, R. Jamieson, E. Morahan, G. Al-Salami, Hani |
| author_facet | Mooranian, A. Negrulj, R. Takechi, R. Jamieson, E. Morahan, G. Al-Salami, Hani |
| author_sort | Mooranian, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 2017 Future Science Ltd. Aim: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due to its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed to examine antidiabetic effects of a PBA, in terms of cellular inflammation and survival and insulin release, in the context of supporting ß-cell delivery and Type 1 diabetic treatment. Materials & methods: 10 formulations were prepared, five without PBA (control) and five with PBA (test). Formulations were used to microencapsulate pancreatic ß cells and the microcapsules were examined for morphology, cell viability, insulin release and inflammation. Results & conclusion: PBA improved cell viability, insulin release and reduced inflammation in a formulation-dependent manner, which suggests potential use in cell delivery and diabetes treatment. |
| first_indexed | 2025-11-14T10:09:34Z |
| format | Journal Article |
| id | curtin-20.500.11937-57300 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:09:34Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-573002017-10-30T08:35:19Z Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells Mooranian, A. Negrulj, R. Takechi, R. Jamieson, E. Morahan, G. Al-Salami, Hani © 2017 2017 Future Science Ltd. Aim: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due to its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed to examine antidiabetic effects of a PBA, in terms of cellular inflammation and survival and insulin release, in the context of supporting ß-cell delivery and Type 1 diabetic treatment. Materials & methods: 10 formulations were prepared, five without PBA (control) and five with PBA (test). Formulations were used to microencapsulate pancreatic ß cells and the microcapsules were examined for morphology, cell viability, insulin release and inflammation. Results & conclusion: PBA improved cell viability, insulin release and reduced inflammation in a formulation-dependent manner, which suggests potential use in cell delivery and diabetes treatment. 2017 Journal Article http://hdl.handle.net/20.500.11937/57300 10.4155/tde-2017-0042 restricted |
| spellingShingle | Mooranian, A. Negrulj, R. Takechi, R. Jamieson, E. Morahan, G. Al-Salami, Hani Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells |
| title | Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells |
| title_full | Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells |
| title_fullStr | Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells |
| title_full_unstemmed | Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells |
| title_short | Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells |
| title_sort | alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells |
| url | http://hdl.handle.net/20.500.11937/57300 |