Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Inc.
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/57230 |
| _version_ | 1848760028030304256 |
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| author | Dmello, D. Ariyanto, I. Estiasari, R. Halstrom, S. Gaff, Jessica Lee, S. Price, Patricia |
| author_facet | Dmello, D. Ariyanto, I. Estiasari, R. Halstrom, S. Gaff, Jessica Lee, S. Price, Patricia |
| author_sort | Dmello, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12 months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 21122 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 21222 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 21122 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872. |
| first_indexed | 2025-11-14T10:09:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-57230 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:09:15Z |
| publishDate | 2017 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-572302018-06-14T00:42:38Z Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy Dmello, D. Ariyanto, I. Estiasari, R. Halstrom, S. Gaff, Jessica Lee, S. Price, Patricia Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12 months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 21122 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 21222 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 21122 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872. 2017 Journal Article http://hdl.handle.net/20.500.11937/57230 10.1016/j.humimm.2017.03.001 Elsevier Inc. fulltext |
| spellingShingle | Dmello, D. Ariyanto, I. Estiasari, R. Halstrom, S. Gaff, Jessica Lee, S. Price, Patricia Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy |
| title | Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy |
| title_full | Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy |
| title_fullStr | Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy |
| title_full_unstemmed | Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy |
| title_short | Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy |
| title_sort | polymorphisms in il10 may alter cd4 t-cell counts in indonesian hiv patients beginning antiretroviral therapy |
| url | http://hdl.handle.net/20.500.11937/57230 |