Genetics of HIV-associated sensory neuropathy and related pain in Africans
Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain fo...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Taylor & Francis Group
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/57025 |
| _version_ | 1848759997013426176 |
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| author | Ngassa Mbenda, H. Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. |
| author_facet | Ngassa Mbenda, H. Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. |
| author_sort | Ngassa Mbenda, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain for which there is no effective analgesic treatment. Genetic factors are implicated, but there is a lack of a comprehensive body of research for African populations. This knowledge gap is even more pertinent as Africans are most affected by HIV. However, recent studies performed in Southern African populations have identified genes displaying potential as genetic markers for HIV-SN and HIV-SN-associated pain in Africans. Here, we review the published studies to describe current knowledge of genetic risk factors for this disease in Africa. |
| first_indexed | 2025-11-14T10:08:46Z |
| format | Journal Article |
| id | curtin-20.500.11937-57025 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:08:46Z |
| publishDate | 2017 |
| publisher | Taylor & Francis Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-570252017-10-02T05:17:44Z Genetics of HIV-associated sensory neuropathy and related pain in Africans Ngassa Mbenda, H. Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain for which there is no effective analgesic treatment. Genetic factors are implicated, but there is a lack of a comprehensive body of research for African populations. This knowledge gap is even more pertinent as Africans are most affected by HIV. However, recent studies performed in Southern African populations have identified genes displaying potential as genetic markers for HIV-SN and HIV-SN-associated pain in Africans. Here, we review the published studies to describe current knowledge of genetic risk factors for this disease in Africa. 2017 Journal Article http://hdl.handle.net/20.500.11937/57025 10.1007/s13365-017-0532-1 Taylor & Francis Group restricted |
| spellingShingle | Ngassa Mbenda, H. Wadley, A. Lombard, Z. Cherry, C. Price, Patricia Kamerman, P. Genetics of HIV-associated sensory neuropathy and related pain in Africans |
| title | Genetics of HIV-associated sensory neuropathy and related pain in Africans |
| title_full | Genetics of HIV-associated sensory neuropathy and related pain in Africans |
| title_fullStr | Genetics of HIV-associated sensory neuropathy and related pain in Africans |
| title_full_unstemmed | Genetics of HIV-associated sensory neuropathy and related pain in Africans |
| title_short | Genetics of HIV-associated sensory neuropathy and related pain in Africans |
| title_sort | genetics of hiv-associated sensory neuropathy and related pain in africans |
| url | http://hdl.handle.net/20.500.11937/57025 |