The Molecular Pathogenesis of Osteosarcoma: A Review
Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60-70, with no significant improvements in prognosis since the advent of multiagent chemothera...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Hindawi Publishing Corporation
2011
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| Online Access: | http://www.hindawi.com/journals/srcm/ http://hdl.handle.net/20.500.11937/57021 |
| _version_ | 1848759995976384512 |
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| author | Choong, P. Broadhead, M. Clark, J. Myers, D. Dass, Crispin |
| author_facet | Choong, P. Broadhead, M. Clark, J. Myers, D. Dass, Crispin |
| author_sort | Choong, P. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60-70, with no significant improvements in prognosis since the advent of multiagent chemotherapy. Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease. As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified. A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies. This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management. |
| first_indexed | 2025-11-14T10:08:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-57021 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:08:45Z |
| publishDate | 2011 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-570212017-10-02T03:52:02Z The Molecular Pathogenesis of Osteosarcoma: A Review Choong, P. Broadhead, M. Clark, J. Myers, D. Dass, Crispin Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60-70, with no significant improvements in prognosis since the advent of multiagent chemotherapy. Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease. As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified. A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies. This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management. 2011 Journal Article http://hdl.handle.net/20.500.11937/57021 10.1155/2011/959248 http://www.hindawi.com/journals/srcm/ http://creativecommons.org/licenses/by/4.0/ Hindawi Publishing Corporation fulltext |
| spellingShingle | Choong, P. Broadhead, M. Clark, J. Myers, D. Dass, Crispin The Molecular Pathogenesis of Osteosarcoma: A Review |
| title | The Molecular Pathogenesis of Osteosarcoma: A Review |
| title_full | The Molecular Pathogenesis of Osteosarcoma: A Review |
| title_fullStr | The Molecular Pathogenesis of Osteosarcoma: A Review |
| title_full_unstemmed | The Molecular Pathogenesis of Osteosarcoma: A Review |
| title_short | The Molecular Pathogenesis of Osteosarcoma: A Review |
| title_sort | molecular pathogenesis of osteosarcoma: a review |
| url | http://www.hindawi.com/journals/srcm/ http://hdl.handle.net/20.500.11937/57021 |