Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes
There is a growing need for the development of nanoparticles, with imaging and drug delivery capabilities, to maintain cellular uptake but avoid protein attachment and recognition. In this study we have demonstrated that nanoparticles consisting of a poly(glycidyl methacrylate) (PGMA) core and a mix...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/56972 |
| _version_ | 1848759982992916480 |
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| author | Clemons, T. Challenor, M. Fitzgerald, Melinda Dunlop, S. Smith, N. Swaminathan Iyer, K. |
| author_facet | Clemons, T. Challenor, M. Fitzgerald, Melinda Dunlop, S. Smith, N. Swaminathan Iyer, K. |
| author_sort | Clemons, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | There is a growing need for the development of nanoparticles, with imaging and drug delivery capabilities, to maintain cellular uptake but avoid protein attachment and recognition. In this study we have demonstrated that nanoparticles consisting of a poly(glycidyl methacrylate) (PGMA) core and a mixed brush architecture of methoxypoly(ethylene glycol) and poly(ethylenimine) (mPEG–PEI) on the surface can meet this need. Surface functionalization with PEI alone results in cellular uptake, but rapid protein attachment whereas PEG alone can avoid protein attachment but to the detriment of cellular uptake. A mixed copolymer brush of both PEI and mPEG provides the ideal balance. |
| first_indexed | 2025-11-14T10:08:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-56972 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:08:32Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-569722018-01-12T01:30:30Z Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes Clemons, T. Challenor, M. Fitzgerald, Melinda Dunlop, S. Smith, N. Swaminathan Iyer, K. There is a growing need for the development of nanoparticles, with imaging and drug delivery capabilities, to maintain cellular uptake but avoid protein attachment and recognition. In this study we have demonstrated that nanoparticles consisting of a poly(glycidyl methacrylate) (PGMA) core and a mixed brush architecture of methoxypoly(ethylene glycol) and poly(ethylenimine) (mPEG–PEI) on the surface can meet this need. Surface functionalization with PEI alone results in cellular uptake, but rapid protein attachment whereas PEG alone can avoid protein attachment but to the detriment of cellular uptake. A mixed copolymer brush of both PEI and mPEG provides the ideal balance. 2016 Journal Article http://hdl.handle.net/20.500.11937/56972 10.1021/acsmacrolett.6b00613 fulltext |
| spellingShingle | Clemons, T. Challenor, M. Fitzgerald, Melinda Dunlop, S. Smith, N. Swaminathan Iyer, K. Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes |
| title | Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes |
| title_full | Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes |
| title_fullStr | Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes |
| title_full_unstemmed | Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes |
| title_short | Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes |
| title_sort | manipulating cellular interactions of poly(glycidyl methacrylate) nanoparticles using mixed polymer brushes |
| url | http://hdl.handle.net/20.500.11937/56972 |