Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective
© 2017, Springer Science+Business Media New York. Human papillomavirus (HPV) associated head and neck squamous cell carcinomas (HNSCCs), have become a serious global health problem. Despite decreases in HPV-negative HNSCCs, the prevalence of HPV-positive HNSCCs has significantly increased. HPV-posit...
| Main Authors: | , |
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| Format: | Journal Article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/56804 |
| _version_ | 1848759942487474176 |
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| author | Aldalwg, M. Brestovac, Brian |
| author_facet | Aldalwg, M. Brestovac, Brian |
| author_sort | Aldalwg, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017, Springer Science+Business Media New York. Human papillomavirus (HPV) associated head and neck squamous cell carcinomas (HNSCCs), have become a serious global health problem. Despite decreases in HPV-negative HNSCCs, the prevalence of HPV-positive HNSCCs has significantly increased. HPV-positive cancers are associated with superior survival outcomes when compared to HPV-negative cancers, which appears likely to be associated with differences in the molecular pathogenesis of the two diseases. While therapies are still problematic, the current HPV vaccine programs hold a promise for the primary prevention of HPV-related HNSCCs and since Australia was the first to introduce a nationwide HPV vaccine program, it is in a unique position to observe the effects of the vaccine on HNSCCs. This review discusses the epidemiological trends associated with HPV in HNSCC, with reference to the differences between HPV-positive and HPV-negative HNSCCs and the prevention potential of HPV vaccines. |
| first_indexed | 2025-11-14T10:07:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-56804 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:07:54Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-568042018-03-29T09:08:24Z Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective Aldalwg, M. Brestovac, Brian © 2017, Springer Science+Business Media New York. Human papillomavirus (HPV) associated head and neck squamous cell carcinomas (HNSCCs), have become a serious global health problem. Despite decreases in HPV-negative HNSCCs, the prevalence of HPV-positive HNSCCs has significantly increased. HPV-positive cancers are associated with superior survival outcomes when compared to HPV-negative cancers, which appears likely to be associated with differences in the molecular pathogenesis of the two diseases. While therapies are still problematic, the current HPV vaccine programs hold a promise for the primary prevention of HPV-related HNSCCs and since Australia was the first to introduce a nationwide HPV vaccine program, it is in a unique position to observe the effects of the vaccine on HNSCCs. This review discusses the epidemiological trends associated with HPV in HNSCC, with reference to the differences between HPV-positive and HPV-negative HNSCCs and the prevention potential of HPV vaccines. 2017 Journal Article http://hdl.handle.net/20.500.11937/56804 10.1007/s12105-017-0780-7 restricted |
| spellingShingle | Aldalwg, M. Brestovac, Brian Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective |
| title | Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective |
| title_full | Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective |
| title_fullStr | Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective |
| title_full_unstemmed | Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective |
| title_short | Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective |
| title_sort | human papillomavirus associated cancers of the head and neck: an australian perspective |
| url | http://hdl.handle.net/20.500.11937/56804 |