Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models

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Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models

Resistance to chemotherapy remains a major challenge in the treatment of human glioblastoma (GBM). Glycogen synthase kinase-3ß (GSK-3ß), a positive regulator of NF-?B–mediated survival and chemoresistance of cancer cells, has been identified as a potential therapeutic target in human GBM. Our object...

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Bibliographic Details
Main Authors:	Ugolkov, A., Qiang, W., Bondarenko, G., Procissi, D., Gaisina, I., James, C., Chandler, J., Kozikowski, A., Gunosewoyo, Hendra, O'Halloran, T., Raizer, J., Mazar, A.
Format:	Journal Article
Published:	2017
Online Access:	http://hdl.handle.net/20.500.11937/56780

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