A potential role for N-acetylcysteine in the management of methamphetamine dependence
Methamphetamine dependence is a growing problem in Australia and globally. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. N-acetylcysteine is one potential pharmacotherapy option. It has received growing attention as a therapy for managing...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Wiley-Blackwell Publishing Ltd.
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/56773 |
| _version_ | 1848759934970232832 |
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| author | McKetin, Rebecca Dean, O. Baker, A. Carter, G. Turner, A. Kelly, P. Berk, M. |
| author_facet | McKetin, Rebecca Dean, O. Baker, A. Carter, G. Turner, A. Kelly, P. Berk, M. |
| author_sort | McKetin, Rebecca |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Methamphetamine dependence is a growing problem in Australia and globally. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. N-acetylcysteine is one potential pharmacotherapy option. It has received growing attention as a therapy for managing addictions because of its capacity to restore homeostasis to brain glutamate systems disrupted in addiction and thereby reduce craving and the risk of relapse. N-acetylcysteine also has antioxidant properties that protect against methamphetamine-induced toxicity and it may therefore assist in the management of the neuropsychiatric and neurocognitive effects of methamphetamine. This commentary overviews the actions of N-acetylcysteine and evidence for its efficacy in treating addiction with a particular focus on its potential utility for methamphetamine dependence. We conclude that the preliminary evidence indicates a need for full-scale trials to definitively establish whether N-acetylcysteine has a therapeutic benefit and the nature of this benefit, for managing methamphetamine dependence. [McKetin R, Dean O, Baker A. L, Carter G, Turner A, Kelly P. J, Berk M. A potential role for N-acetylcysteine in the management of methamphetamine dependence. |
| first_indexed | 2025-11-14T10:07:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-56773 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:07:47Z |
| publishDate | 2017 |
| publisher | Wiley-Blackwell Publishing Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-567732018-01-05T07:45:36Z A potential role for N-acetylcysteine in the management of methamphetamine dependence McKetin, Rebecca Dean, O. Baker, A. Carter, G. Turner, A. Kelly, P. Berk, M. Methamphetamine dependence is a growing problem in Australia and globally. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. N-acetylcysteine is one potential pharmacotherapy option. It has received growing attention as a therapy for managing addictions because of its capacity to restore homeostasis to brain glutamate systems disrupted in addiction and thereby reduce craving and the risk of relapse. N-acetylcysteine also has antioxidant properties that protect against methamphetamine-induced toxicity and it may therefore assist in the management of the neuropsychiatric and neurocognitive effects of methamphetamine. This commentary overviews the actions of N-acetylcysteine and evidence for its efficacy in treating addiction with a particular focus on its potential utility for methamphetamine dependence. We conclude that the preliminary evidence indicates a need for full-scale trials to definitively establish whether N-acetylcysteine has a therapeutic benefit and the nature of this benefit, for managing methamphetamine dependence. [McKetin R, Dean O, Baker A. L, Carter G, Turner A, Kelly P. J, Berk M. A potential role for N-acetylcysteine in the management of methamphetamine dependence. 2017 Journal Article http://hdl.handle.net/20.500.11937/56773 10.1111/dar.12414 Wiley-Blackwell Publishing Ltd. restricted |
| spellingShingle | McKetin, Rebecca Dean, O. Baker, A. Carter, G. Turner, A. Kelly, P. Berk, M. A potential role for N-acetylcysteine in the management of methamphetamine dependence |
| title | A potential role for N-acetylcysteine in the management of methamphetamine dependence |
| title_full | A potential role for N-acetylcysteine in the management of methamphetamine dependence |
| title_fullStr | A potential role for N-acetylcysteine in the management of methamphetamine dependence |
| title_full_unstemmed | A potential role for N-acetylcysteine in the management of methamphetamine dependence |
| title_short | A potential role for N-acetylcysteine in the management of methamphetamine dependence |
| title_sort | potential role for n-acetylcysteine in the management of methamphetamine dependence |
| url | http://hdl.handle.net/20.500.11937/56773 |