Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner
Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
IOS Press
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/56744 |
| _version_ | 1848759928098914304 |
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| author | Gardener, S. Rainey-Smith, S. Sohrabi, H. Weinborn, M. Verdile, Giuseppe Fernando, W. Lim, Y. Harrington, K. Burnham, S. Taddei, K. Masters, C. Macaulay, S. Rowe, C. Ames, D. Maruff, P. Martins, R. |
| author_facet | Gardener, S. Rainey-Smith, S. Sohrabi, H. Weinborn, M. Verdile, Giuseppe Fernando, W. Lim, Y. Harrington, K. Burnham, S. Taddei, K. Masters, C. Macaulay, S. Rowe, C. Ames, D. Maruff, P. Martins, R. |
| author_sort | Gardener, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ?4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-ß (Aß) load in CN older adults, genotyped for APOE ?4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOE ?4 allele non-carriers, and poorer performance in attention in APOE ?4 allele carriers. There were no associations between carbohydrate intake and cerebral Aß load. These results provide support to the idea that decreasing carbohydrate intake may offer neurocognitive benefits, with specific cognitive domains affected in an APOE genotype-dependent manner. These findings warrant further investigation utilizing a longitudinal study design. |
| first_indexed | 2025-11-14T10:07:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-56744 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:07:40Z |
| publishDate | 2017 |
| publisher | IOS Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-567442017-09-27T10:49:01Z Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner Gardener, S. Rainey-Smith, S. Sohrabi, H. Weinborn, M. Verdile, Giuseppe Fernando, W. Lim, Y. Harrington, K. Burnham, S. Taddei, K. Masters, C. Macaulay, S. Rowe, C. Ames, D. Maruff, P. Martins, R. Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ?4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-ß (Aß) load in CN older adults, genotyped for APOE ?4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOE ?4 allele non-carriers, and poorer performance in attention in APOE ?4 allele carriers. There were no associations between carbohydrate intake and cerebral Aß load. These results provide support to the idea that decreasing carbohydrate intake may offer neurocognitive benefits, with specific cognitive domains affected in an APOE genotype-dependent manner. These findings warrant further investigation utilizing a longitudinal study design. 2017 Journal Article http://hdl.handle.net/20.500.11937/56744 10.3233/JAD-161158 IOS Press restricted |
| spellingShingle | Gardener, S. Rainey-Smith, S. Sohrabi, H. Weinborn, M. Verdile, Giuseppe Fernando, W. Lim, Y. Harrington, K. Burnham, S. Taddei, K. Masters, C. Macaulay, S. Rowe, C. Ames, D. Maruff, P. Martins, R. Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner |
| title | Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner |
| title_full | Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner |
| title_fullStr | Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner |
| title_full_unstemmed | Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner |
| title_short | Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner |
| title_sort | increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an apoe genotype-dependent manner |
| url | http://hdl.handle.net/20.500.11937/56744 |