Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer
Pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition (EMT) has gained increasing research f...
| Main Authors: | , , , |
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| Format: | Journal Article |
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BAISHIDENG PUBLISHING GROUP INC
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/56690 |
| _version_ | 1848759914949771264 |
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| author | Elaskalani, O. Razak, N. Falasca, Marco Metharom, Pat |
| author_facet | Elaskalani, O. Razak, N. Falasca, Marco Metharom, Pat |
| author_sort | Elaskalani, O. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition (EMT) has gained increasing research focus. The process is implicated in tumour metastasis, and emerging evidence suggests EMT also contributes or induces chemoresistance in several cancers. Nevertheless, the applicability of therapeutic targeting of EMT faces many challenges. In this mini-review, we summarise the evidence supporting the role of EMT in pancreatic cancer progression, focusing particularly on its association with chemoresistance. |
| first_indexed | 2025-11-14T10:07:28Z |
| format | Journal Article |
| id | curtin-20.500.11937-56690 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:07:28Z |
| publishDate | 2017 |
| publisher | BAISHIDENG PUBLISHING GROUP INC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-566902018-02-12T05:59:35Z Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer Elaskalani, O. Razak, N. Falasca, Marco Metharom, Pat Pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition (EMT) has gained increasing research focus. The process is implicated in tumour metastasis, and emerging evidence suggests EMT also contributes or induces chemoresistance in several cancers. Nevertheless, the applicability of therapeutic targeting of EMT faces many challenges. In this mini-review, we summarise the evidence supporting the role of EMT in pancreatic cancer progression, focusing particularly on its association with chemoresistance. 2017 Journal Article http://hdl.handle.net/20.500.11937/56690 10.4251/wjgo.v9.i1.37 http://creativecommons.org/licenses/by-nc/4.0/ BAISHIDENG PUBLISHING GROUP INC fulltext |
| spellingShingle | Elaskalani, O. Razak, N. Falasca, Marco Metharom, Pat Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer |
| title | Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer |
| title_full | Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer |
| title_fullStr | Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer |
| title_full_unstemmed | Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer |
| title_short | Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer |
| title_sort | epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer |
| url | http://hdl.handle.net/20.500.11937/56690 |