Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury
Traumatic brain injury (TBI) encompasses a broad range of injury mechanisms and severity. A detailed determination of TBI severity can be a complex challenge, with current clinical tools sometimes insufficient to tailor a clinical response to a spectrum of patient needs. Blood biomarkers of TBI may...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/56644 |
| _version_ | 1848759903780339712 |
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| author | Halstrom, A. MacDonald, E. Neil, C. Arendts, G. Fatovich, D. Fitzgerald, Melinda |
| author_facet | Halstrom, A. MacDonald, E. Neil, C. Arendts, G. Fatovich, D. Fitzgerald, Melinda |
| author_sort | Halstrom, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Traumatic brain injury (TBI) encompasses a broad range of injury mechanisms and severity. A detailed determination of TBI severity can be a complex challenge, with current clinical tools sometimes insufficient to tailor a clinical response to a spectrum of patient needs. Blood biomarkers of TBI may supplement clinical assessments but currently available biomarkers have limited sensitivity and specificity. While oxidative stress is known to feature in damage mechanisms following TBI, investigation of blood biomarkers of oxidative stress has been limited. This exploratory pilot study of a subset of 18 trauma patients with TBI of varying severity, quantifies circulating concentrations of the structural damage indicators S100b, and myelin basic protein (MBP), and the biomarkers of oxidative stress hydroxynonenal (HNE), malondialdehyde (MDA), carboxy-methyl-lysine (CML), and 8-hydroxy-2'-deoxy-guanosine (8-OHDG). Significant increases in circulating S100b, MBP, and HNE were observed in TBI patient samples compared to 8 uninjured controls, and there was a significant decrease in CML. This small exploratory study supports the current literature on S100b and MBP elevation in TBI, and reveals potential for the use of peripheral oxidative stress markers to assist in determination of TBI severity. Further investigation is required to validate results and confirm trends. |
| first_indexed | 2025-11-14T10:07:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-56644 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:07:17Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-566442018-01-08T01:17:45Z Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury Halstrom, A. MacDonald, E. Neil, C. Arendts, G. Fatovich, D. Fitzgerald, Melinda Traumatic brain injury (TBI) encompasses a broad range of injury mechanisms and severity. A detailed determination of TBI severity can be a complex challenge, with current clinical tools sometimes insufficient to tailor a clinical response to a spectrum of patient needs. Blood biomarkers of TBI may supplement clinical assessments but currently available biomarkers have limited sensitivity and specificity. While oxidative stress is known to feature in damage mechanisms following TBI, investigation of blood biomarkers of oxidative stress has been limited. This exploratory pilot study of a subset of 18 trauma patients with TBI of varying severity, quantifies circulating concentrations of the structural damage indicators S100b, and myelin basic protein (MBP), and the biomarkers of oxidative stress hydroxynonenal (HNE), malondialdehyde (MDA), carboxy-methyl-lysine (CML), and 8-hydroxy-2'-deoxy-guanosine (8-OHDG). Significant increases in circulating S100b, MBP, and HNE were observed in TBI patient samples compared to 8 uninjured controls, and there was a significant decrease in CML. This small exploratory study supports the current literature on S100b and MBP elevation in TBI, and reveals potential for the use of peripheral oxidative stress markers to assist in determination of TBI severity. Further investigation is required to validate results and confirm trends. 2017 Journal Article http://hdl.handle.net/20.500.11937/56644 10.1016/j.jocn.2016.09.006 Elsevier fulltext |
| spellingShingle | Halstrom, A. MacDonald, E. Neil, C. Arendts, G. Fatovich, D. Fitzgerald, Melinda Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury |
| title | Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury |
| title_full | Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury |
| title_fullStr | Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury |
| title_full_unstemmed | Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury |
| title_short | Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury |
| title_sort | elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury |
| url | http://hdl.handle.net/20.500.11937/56644 |