Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects
Background: People with chronic pain may exhibit pro-nociceptive phenotypes characterised partly by reduced conditioned pain modulation (CPM). Characterising variability in CPM in people with chronic low back pain (CLBP) may inform management. Objectives: To investigate pro/anti-nociceptive effects...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Churchill Livingstone
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/5652 |
| _version_ | 1848744856565841920 |
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| author | Rabey, M. Poon, C. Wray, J. Thamajaree, C. East, R. Slater, Helen |
| author_facet | Rabey, M. Poon, C. Wray, J. Thamajaree, C. East, R. Slater, Helen |
| author_sort | Rabey, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: People with chronic pain may exhibit pro-nociceptive phenotypes characterised partly by reduced conditioned pain modulation (CPM). Characterising variability in CPM in people with chronic low back pain (CLBP) may inform management. Objectives: To investigate pro/anti-nociceptive effects of a CPM protocol in age/sex-matched healthy controls (HCs) and people with CLBP. Design: Case-controlled trial (64 participants/group). Method: The CPM protocol involved: test stimulus (TS) (noxious pressure applied by algometer to lumbar region); conditioning stimulus (CS) (noxious heat applied by thermode to dorsal hand). CPM recruitment was measured by the change in pain intensity (rated on a numeric rating scale (NRS)) of the TS in the presence and absence of the CS. Results: Responses to this CPM protocol were variable for both groups with measures consistent with either inhibitory or facilitatory effects. A significantly greater proportion of facilitatory responses were seen in the CLBP cohort compared to HCs (73% versus 31%). In response to the CS, participants with CLBP demonstrated a mean increase in NRS scores (mean 1.3 points; p<0.001), while HCs did not (mean-0.2 points; p=0.35) and the between-group difference in change scores was significant (mean 1.4 points; p<0.001; effect size (Hedges' g): 1.03). Conclusion: In HCs and participants with CLBP this CPM protocol elicited responses consistent with varying pro/anti-nociceptive effects. The higher proportion of participants with CLBP demonstrating a facilitatory response suggests a pro-nociceptive phenotype may characterise this cohort. |
| first_indexed | 2025-11-14T06:08:07Z |
| format | Journal Article |
| id | curtin-20.500.11937-5652 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:08:07Z |
| publishDate | 2014 |
| publisher | Churchill Livingstone |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-56522017-09-13T14:43:27Z Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects Rabey, M. Poon, C. Wray, J. Thamajaree, C. East, R. Slater, Helen Background: People with chronic pain may exhibit pro-nociceptive phenotypes characterised partly by reduced conditioned pain modulation (CPM). Characterising variability in CPM in people with chronic low back pain (CLBP) may inform management. Objectives: To investigate pro/anti-nociceptive effects of a CPM protocol in age/sex-matched healthy controls (HCs) and people with CLBP. Design: Case-controlled trial (64 participants/group). Method: The CPM protocol involved: test stimulus (TS) (noxious pressure applied by algometer to lumbar region); conditioning stimulus (CS) (noxious heat applied by thermode to dorsal hand). CPM recruitment was measured by the change in pain intensity (rated on a numeric rating scale (NRS)) of the TS in the presence and absence of the CS. Results: Responses to this CPM protocol were variable for both groups with measures consistent with either inhibitory or facilitatory effects. A significantly greater proportion of facilitatory responses were seen in the CLBP cohort compared to HCs (73% versus 31%). In response to the CS, participants with CLBP demonstrated a mean increase in NRS scores (mean 1.3 points; p<0.001), while HCs did not (mean-0.2 points; p=0.35) and the between-group difference in change scores was significant (mean 1.4 points; p<0.001; effect size (Hedges' g): 1.03). Conclusion: In HCs and participants with CLBP this CPM protocol elicited responses consistent with varying pro/anti-nociceptive effects. The higher proportion of participants with CLBP demonstrating a facilitatory response suggests a pro-nociceptive phenotype may characterise this cohort. 2014 Journal Article http://hdl.handle.net/20.500.11937/5652 10.1016/j.math.2015.02.011 Churchill Livingstone restricted |
| spellingShingle | Rabey, M. Poon, C. Wray, J. Thamajaree, C. East, R. Slater, Helen Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects |
| title | Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects |
| title_full | Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects |
| title_fullStr | Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects |
| title_full_unstemmed | Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects |
| title_short | Pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects |
| title_sort | pro-nociceptive and anti-nociceptive effects of a conditioned pain modulation protocol in participants with chronic low back pain and healthy control subjects |
| url | http://hdl.handle.net/20.500.11937/5652 |