Wnt Signalling in Malignant Mesothelioma
The aims of this thesis were to characterise the Wnt signalling system and its pharmacological modulation in mesothelioma derived cell lines using monolayer and three dimensional culture models. Investigations into the effects upon expression of Wnt signal components were performed by inhibiting ta...
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| Format: | Thesis |
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Curtin University
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/56433 |
| _version_ | 1848759987035176960 |
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| author | Richards, Alexander S.K. |
| author_facet | Richards, Alexander S.K. |
| author_sort | Richards, Alexander S.K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The aims of this thesis were to characterise the Wnt signalling system and its pharmacological modulation in mesothelioma derived cell lines using monolayer and three dimensional culture models. Investigations into the effects upon expression of Wnt signal components were performed by inhibiting tankyrase enzymes with the compound XAV939 and histone deacetylase enzymes with suberoylanilide hydroxamic acid. Measurement of effects was carried out using functional assays and RNA sequencing for differential gene expression. |
| first_indexed | 2025-11-14T10:08:36Z |
| format | Thesis |
| id | curtin-20.500.11937-56433 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:08:36Z |
| publishDate | 2016 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-564332018-09-04T06:06:04Z Wnt Signalling in Malignant Mesothelioma Richards, Alexander S.K. The aims of this thesis were to characterise the Wnt signalling system and its pharmacological modulation in mesothelioma derived cell lines using monolayer and three dimensional culture models. Investigations into the effects upon expression of Wnt signal components were performed by inhibiting tankyrase enzymes with the compound XAV939 and histone deacetylase enzymes with suberoylanilide hydroxamic acid. Measurement of effects was carried out using functional assays and RNA sequencing for differential gene expression. 2016 Thesis http://hdl.handle.net/20.500.11937/56433 Curtin University fulltext |
| spellingShingle | Richards, Alexander S.K. Wnt Signalling in Malignant Mesothelioma |
| title | Wnt Signalling in Malignant Mesothelioma |
| title_full | Wnt Signalling in Malignant Mesothelioma |
| title_fullStr | Wnt Signalling in Malignant Mesothelioma |
| title_full_unstemmed | Wnt Signalling in Malignant Mesothelioma |
| title_short | Wnt Signalling in Malignant Mesothelioma |
| title_sort | wnt signalling in malignant mesothelioma |
| url | http://hdl.handle.net/20.500.11937/56433 |