T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP
© 2017 The Authors The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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2017
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| Online Access: | http://hdl.handle.net/20.500.11937/56397 |
| _version_ | 1848759865147654144 |
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| author | Perruzza, L. Gargari, G. Proietti, M. Fosso, B. D'Erchia, A. Faliti, C. Rezzonico-Jost, T. Scribano, D. Mauri, L. Colombo, D. Pellegrini, G. Moregola, A. Mooser, C. Pesole, G. Nicoletti, M. Norata, Giuseppe Geuking, M. McCoy, K. Guglielmetti, S. Grassi, F. |
| author_facet | Perruzza, L. Gargari, G. Proietti, M. Fosso, B. D'Erchia, A. Faliti, C. Rezzonico-Jost, T. Scribano, D. Mauri, L. Colombo, D. Pellegrini, G. Moregola, A. Mooser, C. Pesole, G. Nicoletti, M. Norata, Giuseppe Geuking, M. McCoy, K. Guglielmetti, S. Grassi, F. |
| author_sort | Perruzza, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 The Authors The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help. |
| first_indexed | 2025-11-14T10:06:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-56397 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:06:40Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-563972017-09-13T16:10:39Z T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP Perruzza, L. Gargari, G. Proietti, M. Fosso, B. D'Erchia, A. Faliti, C. Rezzonico-Jost, T. Scribano, D. Mauri, L. Colombo, D. Pellegrini, G. Moregola, A. Mooser, C. Pesole, G. Nicoletti, M. Norata, Giuseppe Geuking, M. McCoy, K. Guglielmetti, S. Grassi, F. © 2017 The Authors The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help. 2017 Journal Article http://hdl.handle.net/20.500.11937/56397 10.1016/j.celrep.2017.02.061 unknown |
| spellingShingle | Perruzza, L. Gargari, G. Proietti, M. Fosso, B. D'Erchia, A. Faliti, C. Rezzonico-Jost, T. Scribano, D. Mauri, L. Colombo, D. Pellegrini, G. Moregola, A. Mooser, C. Pesole, G. Nicoletti, M. Norata, Giuseppe Geuking, M. McCoy, K. Guglielmetti, S. Grassi, F. T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
| title | T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
| title_full | T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
| title_fullStr | T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
| title_full_unstemmed | T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
| title_short | T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
| title_sort | t follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota-derived extracellular atp |
| url | http://hdl.handle.net/20.500.11937/56397 |