MicroRNAs and lipoproteins: A connection beyond atherosclerosis?
MicroRNAs (miRNAs) are short non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level that have been involved in the pathogenesis of a number of cardiovascular diseases. Several miRNAs have been described to finely regulate lipid metabolism and the progression...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Elsevier Ireland
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/56281 |
| _version_ | 1848759833245777920 |
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| author | Norata, Giuseppe Sala, F. Catapano, A. Fernández-Hernando, C. |
| author_facet | Norata, Giuseppe Sala, F. Catapano, A. Fernández-Hernando, C. |
| author_sort | Norata, Giuseppe |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | MicroRNAs (miRNAs) are short non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level that have been involved in the pathogenesis of a number of cardiovascular diseases. Several miRNAs have been described to finely regulate lipid metabolism and the progression and regression of atherosclerosis including, miR-33, miR-122. Of note miR-33a and -33b, represent one of the most interesting and attractive targets for metabolic-related disorders and anti-miR-33 approaches are under intensive investigation.More recently miRNAs were shown to exert their activities in a paracrine manner and also systemically. The latter is possible because lipid-carriers, including lipoproteins, transport and protect miRNAs from degradation in the circulation.This review will present the complex mechanism by which miRNAs regulate lipid metabolism, illustrate how their therapeutical modulation may lead to new treatments for cardiometabolic diseases, and discuss how lipoproteins and other lipid-carriers transport miRNAs in the circulation.The emerging strong connection between miRNAs, lipoproteins and lipid metabolism indicates the existence of a reciprocal modulation that might go beyond atherosclerosis. © 2012 Elsevier Ireland Ltd. |
| first_indexed | 2025-11-14T10:06:10Z |
| format | Journal Article |
| id | curtin-20.500.11937-56281 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:06:10Z |
| publishDate | 2013 |
| publisher | Elsevier Ireland |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-562812018-03-29T09:09:13Z MicroRNAs and lipoproteins: A connection beyond atherosclerosis? Norata, Giuseppe Sala, F. Catapano, A. Fernández-Hernando, C. MicroRNAs (miRNAs) are short non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level that have been involved in the pathogenesis of a number of cardiovascular diseases. Several miRNAs have been described to finely regulate lipid metabolism and the progression and regression of atherosclerosis including, miR-33, miR-122. Of note miR-33a and -33b, represent one of the most interesting and attractive targets for metabolic-related disorders and anti-miR-33 approaches are under intensive investigation.More recently miRNAs were shown to exert their activities in a paracrine manner and also systemically. The latter is possible because lipid-carriers, including lipoproteins, transport and protect miRNAs from degradation in the circulation.This review will present the complex mechanism by which miRNAs regulate lipid metabolism, illustrate how their therapeutical modulation may lead to new treatments for cardiometabolic diseases, and discuss how lipoproteins and other lipid-carriers transport miRNAs in the circulation.The emerging strong connection between miRNAs, lipoproteins and lipid metabolism indicates the existence of a reciprocal modulation that might go beyond atherosclerosis. © 2012 Elsevier Ireland Ltd. 2013 Journal Article http://hdl.handle.net/20.500.11937/56281 10.1016/j.atherosclerosis.2012.11.019 Elsevier Ireland restricted |
| spellingShingle | Norata, Giuseppe Sala, F. Catapano, A. Fernández-Hernando, C. MicroRNAs and lipoproteins: A connection beyond atherosclerosis? |
| title | MicroRNAs and lipoproteins: A connection beyond atherosclerosis? |
| title_full | MicroRNAs and lipoproteins: A connection beyond atherosclerosis? |
| title_fullStr | MicroRNAs and lipoproteins: A connection beyond atherosclerosis? |
| title_full_unstemmed | MicroRNAs and lipoproteins: A connection beyond atherosclerosis? |
| title_short | MicroRNAs and lipoproteins: A connection beyond atherosclerosis? |
| title_sort | micrornas and lipoproteins: a connection beyond atherosclerosis? |
| url | http://hdl.handle.net/20.500.11937/56281 |