The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis
In patients affected by psoriasis, use of a topical formula containing a derivative of zebrafish embryos was associated with reduced skin inflammation and dermal turnover, as well as a generally better outcome. In an attempt to understand the molecular mechanisms lying beyond these findings, we inve...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/56262 |
| _version_ | 1848759828322713600 |
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| author | Norata, Giuseppe Biava, P. Di Pierro, F. |
| author_facet | Norata, Giuseppe Biava, P. Di Pierro, F. |
| author_sort | Norata, Giuseppe |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In patients affected by psoriasis, use of a topical formula containing a derivative of zebrafish embryos was associated with reduced skin inflammation and dermal turnover, as well as a generally better outcome. In an attempt to understand the molecular mechanisms lying beyond these findings, we investigated the anti-proliferative effects of the zebrafish embryos derivative by addressing the mitochondrial function (MTT assay) and cell nuclei distribution (Hoestch staining). In cell cultures stimulated with fetal calf serum (FCS) or epidermal growth factor (EGF), the zebrafish derivative significantly inhibited cell proliferation induced by either approach, although the effect was stronger in cells stimulated with FCS. These results suggest that the zebrafish embryos derivative may dampen increased cell proliferation; this observation may be relevant to cutaneous pathologies related to altered proliferative mechanisms, including psoriasis. |
| first_indexed | 2025-11-14T10:06:05Z |
| format | Journal Article |
| id | curtin-20.500.11937-56262 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:06:05Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-562622017-08-24T02:23:12Z The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis Norata, Giuseppe Biava, P. Di Pierro, F. In patients affected by psoriasis, use of a topical formula containing a derivative of zebrafish embryos was associated with reduced skin inflammation and dermal turnover, as well as a generally better outcome. In an attempt to understand the molecular mechanisms lying beyond these findings, we investigated the anti-proliferative effects of the zebrafish embryos derivative by addressing the mitochondrial function (MTT assay) and cell nuclei distribution (Hoestch staining). In cell cultures stimulated with fetal calf serum (FCS) or epidermal growth factor (EGF), the zebrafish derivative significantly inhibited cell proliferation induced by either approach, although the effect was stronger in cells stimulated with FCS. These results suggest that the zebrafish embryos derivative may dampen increased cell proliferation; this observation may be relevant to cutaneous pathologies related to altered proliferative mechanisms, including psoriasis. 2013 Journal Article http://hdl.handle.net/20.500.11937/56262 restricted |
| spellingShingle | Norata, Giuseppe Biava, P. Di Pierro, F. The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis |
| title | The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis |
| title_full | The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis |
| title_fullStr | The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis |
| title_full_unstemmed | The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis |
| title_short | The zebrafish embryo derivative affects cell viability of epidermal cells: A possible role in the treatment of psoriasis |
| title_sort | zebrafish embryo derivative affects cell viability of epidermal cells: a possible role in the treatment of psoriasis |
| url | http://hdl.handle.net/20.500.11937/56262 |