Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process
The aim of the experiments in this research was to produce a coated superparamagnetic iron oxide nanoparticle (SPION) product that may be used as a contrasting agent for MRI. There are several methods that can be employed to coat SPIONs. However, many of the current methods employ toxic organic solv...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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CSIRO Publishing
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/56205 |
| _version_ | 1848759813457051648 |
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| author | Lam, U. Yoganathan, R. Carr, A. Mammucari, R. Foster, Neil |
| author_facet | Lam, U. Yoganathan, R. Carr, A. Mammucari, R. Foster, Neil |
| author_sort | Lam, U. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The aim of the experiments in this research was to produce a coated superparamagnetic iron oxide nanoparticle (SPION) product that may be used as a contrasting agent for MRI. There are several methods that can be employed to coat SPIONs. However, many of the current methods employ toxic organic solvents which can be difficult to remove from the product solution. The encapsulation and characterization of SPIONs in Eudragit was done using a supercritical antisolvent system (SAS) with ethanol as the solvent and supercritical carbon dioxide (SC-CO 2 ) as the antisolvent. Particles of diameters less than 200nm were produced which had preserved superparamagnetic properties. An encapsulation efficiency of 70% was achieved. This compilation © CSIRO 2011. |
| first_indexed | 2025-11-14T10:05:51Z |
| format | Journal Article |
| id | curtin-20.500.11937-56205 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:05:51Z |
| publishDate | 2012 |
| publisher | CSIRO Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-562052017-09-13T16:10:28Z Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process Lam, U. Yoganathan, R. Carr, A. Mammucari, R. Foster, Neil The aim of the experiments in this research was to produce a coated superparamagnetic iron oxide nanoparticle (SPION) product that may be used as a contrasting agent for MRI. There are several methods that can be employed to coat SPIONs. However, many of the current methods employ toxic organic solvents which can be difficult to remove from the product solution. The encapsulation and characterization of SPIONs in Eudragit was done using a supercritical antisolvent system (SAS) with ethanol as the solvent and supercritical carbon dioxide (SC-CO 2 ) as the antisolvent. Particles of diameters less than 200nm were produced which had preserved superparamagnetic properties. An encapsulation efficiency of 70% was achieved. This compilation © CSIRO 2011. 2012 Journal Article http://hdl.handle.net/20.500.11937/56205 10.1071/CH11360 CSIRO Publishing restricted |
| spellingShingle | Lam, U. Yoganathan, R. Carr, A. Mammucari, R. Foster, Neil Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process |
| title | Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process |
| title_full | Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process |
| title_fullStr | Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process |
| title_full_unstemmed | Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process |
| title_short | Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process |
| title_sort | encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process |
| url | http://hdl.handle.net/20.500.11937/56205 |