Characterization and in vitro release studies of oral microbeads containing thiolated pectin-doxorubicin conjugates for colorectal cancer treatment

QR Code

Characterization and in vitro release studies of oral microbeads containing thiolated pectin-doxorubicin conjugates for colorectal cancer treatment

© 2017 Shenyang Pharmaceutical University. Novel oral microbeads were developed based on a biopolymer-drug conjugate of doxorubicin (DOX) conjugated with thiolated pectin via reducible disulfide bonds. The microbeads were fabricated by ionotropic gelation with cations such as Al 3+ , Ca 2+ and Zn 2...

Full description

Bibliographic Details
Main Authors:	Cheewatanakornkool, K., Niratisai, S., Manchun, S., Dass, Crispin, Sriamornsak, P.
Format:	Journal Article
Published:	2017
Online Access:	http://hdl.handle.net/20.500.11937/56128

Similar Items

Redox-responsive microbeads containing thiolated pectin-doxorubicin conjugate inhibit tumor growth and metastasis: An in vitro and in vivo study
by: Cheewatanakornkool, K., et al.
Published: (2018)

Thiolated pectin–doxorubicin conjugates: Synthesis, characterization and anticancer activity studies
by: Cheewatanakornkool, K., et al.
Published: (2017)

Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer
by: Manchun, S., et al.
Published: (2015)

Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin
by: Manchun, S., et al.
Published: (2016)

Novel pH-responsive dextrin nanogels for doxorubicin delivery to cancer cells with reduced cytotoxicity to cardiomyocytes and stem cells
by: Manchun, S., et al.
Published: (2014)

Doxorubicin: The dogma and the bone
by: Wong, J., et al.
Published: (2016)

Nucleotropic doxorubicin nanoparticles decrease cancer cell viability, destroy mitochondria, induce autophagy and enhance tumour necrosis
by: Friedhuber, A., et al.
Published: (2015)

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
by: Tacar, O., et al.
Published: (2013)

Designing nanoemulsion templates for fabrication of dextrin nanoparticles via emulsion cross-linking technique
by: Manchun, S., et al.
Published: (2014)

Targeted therapy for cancer using pH-responsive nanocarrier systems
by: Manchun, S., et al.
Published: (2012)

Doxorubicin action on mitochondria: relevance to osteosarcoma therapy?
by: Armstrong, J., et al.
Published: (2015)

Anti-Tumour Effect of a Chitosan Delivery System for Doxorubicin
by: Tan, M., et al.
Published: (2010)

Doxorubicin, mesenchymal stem cell toxicity and antitumour activity: implications for clinical use
by: Baxter-Holland, M., et al.
Published: (2018)

Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes?
by: Tacar, O., et al.
Published: (2013)

In vitro delivery and controlled release of doxorubicin for targeting osteosarcoma bone cancer
by: Kamba, Shafiu Abdullahi, et al.
Published: (2013)

Nanoencapsulation Of Thiolated Sodium Alginate: Synthesis, Drug Release And Cellular Uptake Studies
by: Chiu, Hocking
Published: (2018)

Co-nanoencapsulated doxorubicin and Dz13 control osteosarcoma progression in a murine model
by: Tan, M., et al.
Published: (2013)

Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates
by: Purdie, Laura, et al.
Published: (2016)

Cardiomyocyte apoptosis vs autophagy with prolonged doxorubicin treatment: Comparison with osteosarcoma cells
by: Tacar, O., et al.
Published: (2015)

Feeding behaviour of Tilapia (Oreochromis sp.) fingerlings to microbeads
by: Chua, Chiew Peng, et al.
Published: (2019)

Modification of Alginate Controlled-Release Formulations of Alachlor and Diuron with Pectin: Their Release Kinetics and Efficacy
by: Basari, Sopiah
Published: (2003)

An electrochemical DNA biosensor based gold-thiolate conjugation utilizing ruthenium complex [Ru(dppz)2(qtpy)]Cl2
by: Foo, K. L., et al.
Published: (2016)

Effect of adding pectin to the controlled-release formulation of alachlor and diuron
by: Omar, Dzolkhifli

Effects of mixing and conjugation process with pea protein isolate on functional properties of pectin in emulsions
by: Tamnak, Sahar
Published: (2015)

Biodegradable drug delivery systems for cancer therapy
by: Wong, T., et al.
Published: (2017)

Netrin-1 in the developing enteric nervous system and colorectal cancer
by: Ko, S., et al.
Published: (2012)

Encapsulation properties, release behavior and physicochemical characteristics of water-in-oil-in-water (W/O/W) emulsion stabilized with pectin–pea protein isolate conjugate and Tween 80
by: Tamnak, Sahar, et al.
Published: (2016)

Resonance-Based Detection of Magnetic Nanoparticles and Microbeads Using Nanopatterned Ferromagnets
by: Sushruth, M., et al.
Published: (2016)

Doxorubicin-Conjugated Mesoporous Magnetic Colloidal Nanocrystal Clusters Stabilized by Polysaccharide as a Smart Anticancer Drug Vehicle
by: Li, D., et al.
Published: (2012)

Sugar beet pectin–sodium caseinate conjugate stabilised emulsions: An investigation into the relationship between interfacial and bulk rheological properties for varying types of conjugates
by: Zhang, Juyang
Published: (2018)

Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer
by: Ko, S., et al.
Published: (2014)

Phosphane metal(1) thiolate complexes and their crystal structures
by: Yeo, Chien Ing *
Published: (2016)

Phosphane metal(I) thiolate complexes and their crystal structures
by: Yeo, Chien Ing *
Published: (2016)

An electrochemical DNA biosensor based gold-thiolate conjugation utilizing ruthenium complex [Ru(dppz)<inf>2</inf>(qtpy)]Cl<inf>2</inf>
by: Foo, K.L., et al.
Published: (2017)

Screening of electrosprayoperating parameters in the production of alginate–royal jelly microbeads using factorial design
by: Mohd Rus, Shaiqah, et al.
Published: (2020)

Novel lactoferrin-loaded alginate microbeads display anti-Clostridium difficile defence properties
by: Monaghan, Tanya M., et al.
Published: (2018)

Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
by: Mohd Mokhtar, Mohammad Tarmizi
Published: (2014)

Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release
by: Siddiqui, Nabil A., et al.
Published: (2017)

In-vitro evaluation of enteric coated insulin tablets containing absorption enhancer and enzyme inhibitor
by: Wong, C., et al.
Published: (2017)

Screening of electrospray operating parameters in the production of alginate-royal jelly microbeads using factorial design
by: Mohd Rus, Shaiqah, et al.
Published: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jb757br7a9mokvknipmgvln6n0