Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process
© 2017 Elsevier B.V. The Atomized Rapid Injection Solvent Extraction (ARISE) process is a new technique for the production of micron-size particles using a supercritical antisolvent. Scale-up of the process can be achieved simply by maintaining the antisolvent/solvent ratios and pressure differentia...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Elsevier BV
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/55964 |
| _version_ | 1848759751547027456 |
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| author | Kurniawansyah, F. Mammucari, R. Tandya, A. Foster, Neil |
| author_facet | Kurniawansyah, F. Mammucari, R. Tandya, A. Foster, Neil |
| author_sort | Kurniawansyah, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Elsevier B.V. The Atomized Rapid Injection Solvent Extraction (ARISE) process is a new technique for the production of micron-size particles using a supercritical antisolvent. Scale-up of the process can be achieved simply by maintaining the antisolvent/solvent ratios and pressure differentials while increasing batch volumes. In this work, two model compounds, para-coumaric acid (PCA) and hydroxypropyl-ß-cyclodextrin (HPßCD), were processed using ARISE at different operating scales. The batch size for PCA varied between 0.2 g/batch and 1.6 g/batch, while the batch size of HPßCD varied from 0.8 g/batch to 13.9 g/batch. The economic evaluation of the process was based on production rates between 2 and 10 t/a, which are typical for high-specialty grade chemicals. Capital investment and production costs were estimated using the scaling–exponential method. Investment costs were estimated between 190 and 950 US$/kg of product while production costs were calculated between 52 and 255 US$/kg of product (year 2015). The figures indicate that ARISE can be economically viable for the manufacturing of specialty chemicals as pharmaceuticals. |
| first_indexed | 2025-11-14T10:04:52Z |
| format | Journal Article |
| id | curtin-20.500.11937-55964 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:04:52Z |
| publishDate | 2017 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-559642017-09-13T16:11:34Z Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process Kurniawansyah, F. Mammucari, R. Tandya, A. Foster, Neil © 2017 Elsevier B.V. The Atomized Rapid Injection Solvent Extraction (ARISE) process is a new technique for the production of micron-size particles using a supercritical antisolvent. Scale-up of the process can be achieved simply by maintaining the antisolvent/solvent ratios and pressure differentials while increasing batch volumes. In this work, two model compounds, para-coumaric acid (PCA) and hydroxypropyl-ß-cyclodextrin (HPßCD), were processed using ARISE at different operating scales. The batch size for PCA varied between 0.2 g/batch and 1.6 g/batch, while the batch size of HPßCD varied from 0.8 g/batch to 13.9 g/batch. The economic evaluation of the process was based on production rates between 2 and 10 t/a, which are typical for high-specialty grade chemicals. Capital investment and production costs were estimated using the scaling–exponential method. Investment costs were estimated between 190 and 950 US$/kg of product while production costs were calculated between 52 and 255 US$/kg of product (year 2015). The figures indicate that ARISE can be economically viable for the manufacturing of specialty chemicals as pharmaceuticals. 2017 Journal Article http://hdl.handle.net/20.500.11937/55964 10.1016/j.supflu.2017.03.006 Elsevier BV restricted |
| spellingShingle | Kurniawansyah, F. Mammucari, R. Tandya, A. Foster, Neil Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process |
| title | Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process |
| title_full | Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process |
| title_fullStr | Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process |
| title_full_unstemmed | Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process |
| title_short | Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process |
| title_sort | scale - up and economic evaluation of the atomized rapid injection solvent extraction process |
| url | http://hdl.handle.net/20.500.11937/55964 |