Duration of protection after first dose of acellular pertussis vaccine in infants
OBJECTIVE: Data on the effectiveness of the diphtheria- tetanus-acellular pertussis (DTaP) vaccine in the first 4 years of life are sparse. We evaluated the vaccine effectiveness (VE) of 1 and 2 doses of DTaP before 6 months of age and of 3 doses from 6 months of age in Australia, where, since 2003,...
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| Format: | Journal Article |
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American Academy of Pediatrics
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/55823 |
| _version_ | 1848759716782538752 |
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| author | Quinn, H. Snelling, Thomas Macartney, K. McIntyre, P. |
| author_facet | Quinn, H. Snelling, Thomas Macartney, K. McIntyre, P. |
| author_sort | Quinn, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | OBJECTIVE: Data on the effectiveness of the diphtheria- tetanus-acellular pertussis (DTaP) vaccine in the first 4 years of life are sparse. We evaluated the vaccine effectiveness (VE) of 1 and 2 doses of DTaP before 6 months of age and of 3 doses from 6 months of age in Australia, where, since 2003, a fourth dose is not given until 4 years. METHODS: We matched reported pertussis cases aged 2 to 47 months between January 2005 and December 2009 to controls from a population-based immunization register by date of birth and region of residence. VE by number of doses and age group was calculated as (1 - odds ratio) x 100%. RESULTS: VE against hospitalization increased from 55.3% (95% confidence interval [CI], 42.7%-65.1%) for 1 dose before 4 months of age to 83.0% (95% CI, 70.2%-90.3%) for 2 doses before 6 months. The VE of 3 doses of DTaP against all reported pertussis was 83.5% (95% CI, 79.1%-87.8%) between 6 and 11 months, declining to 70.7% (95% CI, 64.5%-75.8%) between 2 and 3 years of age and 59.2% (95% CI, 51.0%-66.0%) between 3 and 4 years of age. CONCLUSIONS: DTaP provided good protection against pertussis in the first year of life from the first dose. Without a booster dose, the effectiveness of 3 doses waned more rapidly from 2 to 4 years of age than previously documented for children > 6 years of age who had received 5 doses. Copyright © 2014 by the American Academy of Pediatrics. |
| first_indexed | 2025-11-14T10:04:19Z |
| format | Journal Article |
| id | curtin-20.500.11937-55823 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:04:19Z |
| publishDate | 2014 |
| publisher | American Academy of Pediatrics |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-558232017-09-13T16:10:39Z Duration of protection after first dose of acellular pertussis vaccine in infants Quinn, H. Snelling, Thomas Macartney, K. McIntyre, P. OBJECTIVE: Data on the effectiveness of the diphtheria- tetanus-acellular pertussis (DTaP) vaccine in the first 4 years of life are sparse. We evaluated the vaccine effectiveness (VE) of 1 and 2 doses of DTaP before 6 months of age and of 3 doses from 6 months of age in Australia, where, since 2003, a fourth dose is not given until 4 years. METHODS: We matched reported pertussis cases aged 2 to 47 months between January 2005 and December 2009 to controls from a population-based immunization register by date of birth and region of residence. VE by number of doses and age group was calculated as (1 - odds ratio) x 100%. RESULTS: VE against hospitalization increased from 55.3% (95% confidence interval [CI], 42.7%-65.1%) for 1 dose before 4 months of age to 83.0% (95% CI, 70.2%-90.3%) for 2 doses before 6 months. The VE of 3 doses of DTaP against all reported pertussis was 83.5% (95% CI, 79.1%-87.8%) between 6 and 11 months, declining to 70.7% (95% CI, 64.5%-75.8%) between 2 and 3 years of age and 59.2% (95% CI, 51.0%-66.0%) between 3 and 4 years of age. CONCLUSIONS: DTaP provided good protection against pertussis in the first year of life from the first dose. Without a booster dose, the effectiveness of 3 doses waned more rapidly from 2 to 4 years of age than previously documented for children > 6 years of age who had received 5 doses. Copyright © 2014 by the American Academy of Pediatrics. 2014 Journal Article http://hdl.handle.net/20.500.11937/55823 10.1542/peds.2013-3181 American Academy of Pediatrics unknown |
| spellingShingle | Quinn, H. Snelling, Thomas Macartney, K. McIntyre, P. Duration of protection after first dose of acellular pertussis vaccine in infants |
| title | Duration of protection after first dose of acellular pertussis vaccine in infants |
| title_full | Duration of protection after first dose of acellular pertussis vaccine in infants |
| title_fullStr | Duration of protection after first dose of acellular pertussis vaccine in infants |
| title_full_unstemmed | Duration of protection after first dose of acellular pertussis vaccine in infants |
| title_short | Duration of protection after first dose of acellular pertussis vaccine in infants |
| title_sort | duration of protection after first dose of acellular pertussis vaccine in infants |
| url | http://hdl.handle.net/20.500.11937/55823 |