Role of epigenetic modulation in cancer stem cell fate
© 2017 Elsevier Ltd A sub-population of the tumor micro-environment consists of cancer stem cells (CSCs), which are responsible for the initiation and recurrence of cancer. Recently, epigenetic processes such as DNA methylation, histone modification, and chromatin remodeling have been found to be in...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Pergamon
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/55734 |
| _version_ | 1848759693970767872 |
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| author | Deshmukh, A. Binju, M. Arfuso, Frank Newsholme, Philip Dharmarajan, Arunasalam |
| author_facet | Deshmukh, A. Binju, M. Arfuso, Frank Newsholme, Philip Dharmarajan, Arunasalam |
| author_sort | Deshmukh, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Elsevier Ltd A sub-population of the tumor micro-environment consists of cancer stem cells (CSCs), which are responsible for the initiation and recurrence of cancer. Recently, epigenetic processes such as DNA methylation, histone modification, and chromatin remodeling have been found to be involved in inducing epigenetic factors in CSCs. Most of these processes, such as DNA methylation, generally occur in the genome that is rich in Cytosine-Guanine repeat sequences, also known as CpG islands, which are distributed throughout the human genome. The Polycomb gene (PcG) complex is a chromatin modifier facilitating the maintenance of embryonic and adult stem cells. Recent evidence suggests that the PcG is also involved in maintaining CSC stemness. We have presented various aspects and examples of how epigenetic modulation may drive or promote tumorigenesis and metastasis by alteration of key transcriptomic programs and signaling pathways in CSCs. |
| first_indexed | 2025-11-14T10:03:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-55734 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:03:57Z |
| publishDate | 2017 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-557342017-09-13T16:10:19Z Role of epigenetic modulation in cancer stem cell fate Deshmukh, A. Binju, M. Arfuso, Frank Newsholme, Philip Dharmarajan, Arunasalam © 2017 Elsevier Ltd A sub-population of the tumor micro-environment consists of cancer stem cells (CSCs), which are responsible for the initiation and recurrence of cancer. Recently, epigenetic processes such as DNA methylation, histone modification, and chromatin remodeling have been found to be involved in inducing epigenetic factors in CSCs. Most of these processes, such as DNA methylation, generally occur in the genome that is rich in Cytosine-Guanine repeat sequences, also known as CpG islands, which are distributed throughout the human genome. The Polycomb gene (PcG) complex is a chromatin modifier facilitating the maintenance of embryonic and adult stem cells. Recent evidence suggests that the PcG is also involved in maintaining CSC stemness. We have presented various aspects and examples of how epigenetic modulation may drive or promote tumorigenesis and metastasis by alteration of key transcriptomic programs and signaling pathways in CSCs. 2017 Journal Article http://hdl.handle.net/20.500.11937/55734 10.1016/j.biocel.2017.07.003 Pergamon restricted |
| spellingShingle | Deshmukh, A. Binju, M. Arfuso, Frank Newsholme, Philip Dharmarajan, Arunasalam Role of epigenetic modulation in cancer stem cell fate |
| title | Role of epigenetic modulation in cancer stem cell fate |
| title_full | Role of epigenetic modulation in cancer stem cell fate |
| title_fullStr | Role of epigenetic modulation in cancer stem cell fate |
| title_full_unstemmed | Role of epigenetic modulation in cancer stem cell fate |
| title_short | Role of epigenetic modulation in cancer stem cell fate |
| title_sort | role of epigenetic modulation in cancer stem cell fate |
| url | http://hdl.handle.net/20.500.11937/55734 |