Oligomerization and toxicity of Aß fusion proteins
This study has found that the Maltose binding protein Aß42 fusion protein (MBP-Aß42) forms soluble oligomers while the shorter MBP-Aß16 fusion and control MBP did not. MBP-Aß42, but neither MBP-Aß16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cel...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/5565 |
| _version_ | 1848744832527237120 |
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| author | Caine, J. Bharadwaj, Prashant Sankovich, S. Ciccotosto, G. Streltsov, V. Varghese, J. |
| author_facet | Caine, J. Bharadwaj, Prashant Sankovich, S. Ciccotosto, G. Streltsov, V. Varghese, J. |
| author_sort | Caine, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This study has found that the Maltose binding protein Aß42 fusion protein (MBP-Aß42) forms soluble oligomers while the shorter MBP-Aß16 fusion and control MBP did not. MBP-Aß42, but neither MBP-Aß16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-Aß42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further Aß42 characterization. © 2011 . |
| first_indexed | 2025-11-14T06:07:44Z |
| format | Journal Article |
| id | curtin-20.500.11937-5565 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:07:44Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-55652017-09-13T14:41:03Z Oligomerization and toxicity of Aß fusion proteins Caine, J. Bharadwaj, Prashant Sankovich, S. Ciccotosto, G. Streltsov, V. Varghese, J. This study has found that the Maltose binding protein Aß42 fusion protein (MBP-Aß42) forms soluble oligomers while the shorter MBP-Aß16 fusion and control MBP did not. MBP-Aß42, but neither MBP-Aß16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-Aß42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further Aß42 characterization. © 2011 . 2011 Journal Article http://hdl.handle.net/20.500.11937/5565 10.1016/j.bbrc.2011.05.029 restricted |
| spellingShingle | Caine, J. Bharadwaj, Prashant Sankovich, S. Ciccotosto, G. Streltsov, V. Varghese, J. Oligomerization and toxicity of Aß fusion proteins |
| title | Oligomerization and toxicity of Aß fusion proteins |
| title_full | Oligomerization and toxicity of Aß fusion proteins |
| title_fullStr | Oligomerization and toxicity of Aß fusion proteins |
| title_full_unstemmed | Oligomerization and toxicity of Aß fusion proteins |
| title_short | Oligomerization and toxicity of Aß fusion proteins |
| title_sort | oligomerization and toxicity of aß fusion proteins |
| url | http://hdl.handle.net/20.500.11937/5565 |