An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode

Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the humoral arm of innate immunity. In four different models of tissue damage in mice, PTX3 deficiency was associated with increased fibrin deposition and persistence, and thicker clots, followed by increased col...

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Bibliographic Details
Main Authors: Doni, A., Musso, T., Morone, D., Bastone, A., Zambelli, V., Sironi, M., Castagnoli, C., Cambieri, I., Stravalaci, M., Pasqualini, F., Laface, I., Valentino, S., Tartari, S., Ponzetta, A., Maina, V., Barbieri, S., Tremoli, E., Catapano, A., Norata, Giuseppe, Bottazzi, B., Garlanda, C., Mantovani, A.
Format: Journal Article
Published: Rockefeller University Press 2015
Online Access:http://hdl.handle.net/20.500.11937/55603

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