The Wnt signaling pathways and cell adhesion
In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis. It is well known that the Wnt signaling p...
| Main Authors: | , |
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| Format: | Journal Article |
| Published: |
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/5547 |
| _version_ | 1848744827372437504 |
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| author | Amin, N. Vincan, Elizabeth |
| author_facet | Amin, N. Vincan, Elizabeth |
| author_sort | Amin, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis. It is well known that the Wnt signaling pathways affect adhesion and migration via downstream effectors. Canonical Wnt signaling regulates cell adhesion by regulating the stability of beta-Catenin, a component of the adherens junction. Whereas, non-canonical signaling modulates cytoskeletal dynamics by regulating the activity of downstream effectors that function to organize the cytoskeleton. Recent studies have uncovered a multitude of points of crosstalk between the Wnt pathways and the mechanisms that control cellular architecture, from the level of receptors to the level of transcription. At the same time, cellular mechanisms that are responsible for the regulation of adhesion and migration also function to modulate the activity of several Wnt pathway components. Uncovering these points of crosstalk may lead to better understanding and treatment of the processes that can lead to tumorgenesis. |
| first_indexed | 2025-11-14T06:07:39Z |
| format | Journal Article |
| id | curtin-20.500.11937-5547 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:07:39Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-55472017-09-13T14:38:34Z The Wnt signaling pathways and cell adhesion Amin, N. Vincan, Elizabeth In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis. It is well known that the Wnt signaling pathways affect adhesion and migration via downstream effectors. Canonical Wnt signaling regulates cell adhesion by regulating the stability of beta-Catenin, a component of the adherens junction. Whereas, non-canonical signaling modulates cytoskeletal dynamics by regulating the activity of downstream effectors that function to organize the cytoskeleton. Recent studies have uncovered a multitude of points of crosstalk between the Wnt pathways and the mechanisms that control cellular architecture, from the level of receptors to the level of transcription. At the same time, cellular mechanisms that are responsible for the regulation of adhesion and migration also function to modulate the activity of several Wnt pathway components. Uncovering these points of crosstalk may lead to better understanding and treatment of the processes that can lead to tumorgenesis. 2012 Journal Article http://hdl.handle.net/20.500.11937/5547 10.2741/3957 restricted |
| spellingShingle | Amin, N. Vincan, Elizabeth The Wnt signaling pathways and cell adhesion |
| title | The Wnt signaling pathways and cell adhesion |
| title_full | The Wnt signaling pathways and cell adhesion |
| title_fullStr | The Wnt signaling pathways and cell adhesion |
| title_full_unstemmed | The Wnt signaling pathways and cell adhesion |
| title_short | The Wnt signaling pathways and cell adhesion |
| title_sort | wnt signaling pathways and cell adhesion |
| url | http://hdl.handle.net/20.500.11937/5547 |