Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population
Background and Purpose: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
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Public Library of Science
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/55416 |
| _version_ | 1848759615296110592 |
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| author | Predazzi, I. Norata, Giuseppe Vecchione, L. Garlaschelli, K. Amati, F. Grigore, L. Cutuli, L. Pirillo, A. Tramontana, S. Romeo, F. Novelli, G. Catapano, A. |
| author_facet | Predazzi, I. Norata, Giuseppe Vecchione, L. Garlaschelli, K. Amati, F. Grigore, L. Cutuli, L. Pirillo, A. Tramontana, S. Romeo, F. Novelli, G. Catapano, A. |
| author_sort | Predazzi, I. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background and Purpose: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study). Results: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers. Conclusions: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process. © 2012 Predazzi et al. |
| first_indexed | 2025-11-14T10:02:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-55416 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:02:42Z |
| publishDate | 2012 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-554162018-01-10T03:44:07Z Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population Predazzi, I. Norata, Giuseppe Vecchione, L. Garlaschelli, K. Amati, F. Grigore, L. Cutuli, L. Pirillo, A. Tramontana, S. Romeo, F. Novelli, G. Catapano, A. Background and Purpose: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study). Results: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers. Conclusions: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process. © 2012 Predazzi et al. 2012 Journal Article http://hdl.handle.net/20.500.11937/55416 10.1371/journal.pone.0031086 http://creativecommons.org/licenses/by/3.0/ Public Library of Science fulltext |
| spellingShingle | Predazzi, I. Norata, Giuseppe Vecchione, L. Garlaschelli, K. Amati, F. Grigore, L. Cutuli, L. Pirillo, A. Tramontana, S. Romeo, F. Novelli, G. Catapano, A. Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population |
| title | Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population |
| title_full | Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population |
| title_fullStr | Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population |
| title_full_unstemmed | Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population |
| title_short | Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population |
| title_sort | association between olr1 k167n snp and intima media thickness of the common carotid artery in the general population |
| url | http://hdl.handle.net/20.500.11937/55416 |