High density lipoproteins and atherosclerosis: Emerging aspects
High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant antiatherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of...
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| Format: | Journal Article |
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Chinese P L A General Hospital * Institute of Geriatric Cardiology
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/55372 |
| _version_ | 1848759604475854848 |
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| author | Sala, F. Catapano, A. Norata, Giuseppe |
| author_facet | Sala, F. Catapano, A. Norata, Giuseppe |
| author_sort | Sala, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant antiatherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis. © 2012 JGC All rights reserved. |
| first_indexed | 2025-11-14T10:02:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-55372 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:02:31Z |
| publishDate | 2012 |
| publisher | Chinese P L A General Hospital * Institute of Geriatric Cardiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-553722018-03-29T09:09:35Z High density lipoproteins and atherosclerosis: Emerging aspects Sala, F. Catapano, A. Norata, Giuseppe High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant antiatherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis. © 2012 JGC All rights reserved. 2012 Journal Article http://hdl.handle.net/20.500.11937/55372 10.3724/SP.J.1263.2011.12282 Chinese P L A General Hospital * Institute of Geriatric Cardiology restricted |
| spellingShingle | Sala, F. Catapano, A. Norata, Giuseppe High density lipoproteins and atherosclerosis: Emerging aspects |
| title | High density lipoproteins and atherosclerosis: Emerging aspects |
| title_full | High density lipoproteins and atherosclerosis: Emerging aspects |
| title_fullStr | High density lipoproteins and atherosclerosis: Emerging aspects |
| title_full_unstemmed | High density lipoproteins and atherosclerosis: Emerging aspects |
| title_short | High density lipoproteins and atherosclerosis: Emerging aspects |
| title_sort | high density lipoproteins and atherosclerosis: emerging aspects |
| url | http://hdl.handle.net/20.500.11937/55372 |