Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals
© 2017 The Author(s) Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understo...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/55371 |
| _version_ | 1848759604195885056 |
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| author | Mauro, C. Smith, J. Cucchi, D. Coe, D. Fu, H. Bonacina, F. Baragetti, A. Cermenati, G. Caruso, D. Mitro, N. Catapano, A. Ammirati, E. Longhi, M. Okkenhaug, K. Norata, Giuseppe Marelli-Berg, F. |
| author_facet | Mauro, C. Smith, J. Cucchi, D. Coe, D. Fu, H. Bonacina, F. Baragetti, A. Cermenati, G. Caruso, D. Mitro, N. Catapano, A. Ammirati, E. Longhi, M. Okkenhaug, K. Norata, Giuseppe Marelli-Berg, F. |
| author_sort | Mauro, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 The Author(s) Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether saturated fatty acid-induced metabolic stress affects differentiation and trafficking patterns of CD4 + T cells. Memory CD4 + T cells primed in high-fat diet-fed donors preferentially migrated to non-lymphoid, inflammatory sites, independent of the metabolic status of the hosts. This was due to biased CD4 + T cell differentiation into CD44 hi -CCR7 lo -CD62L lo -CXCR3 + -LFA1 + effector memory-like T cells upon priming in high-fat diet-fed animals. Similar phenotype was observed in obese subjects in a cohort of free-living people. This developmental bias was independent of any crosstalk between CD4 + T cells and dendritic cells and was mediated via direct exposure of CD4 + T cells to palmitate, leading to increased activation of a PI3K p110d-Akt-dependent pathway upon priming. |
| first_indexed | 2025-11-14T10:02:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-55371 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:02:31Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-553712023-08-02T06:39:09Z Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals Mauro, C. Smith, J. Cucchi, D. Coe, D. Fu, H. Bonacina, F. Baragetti, A. Cermenati, G. Caruso, D. Mitro, N. Catapano, A. Ammirati, E. Longhi, M. Okkenhaug, K. Norata, Giuseppe Marelli-Berg, F. © 2017 The Author(s) Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether saturated fatty acid-induced metabolic stress affects differentiation and trafficking patterns of CD4 + T cells. Memory CD4 + T cells primed in high-fat diet-fed donors preferentially migrated to non-lymphoid, inflammatory sites, independent of the metabolic status of the hosts. This was due to biased CD4 + T cell differentiation into CD44 hi -CCR7 lo -CD62L lo -CXCR3 + -LFA1 + effector memory-like T cells upon priming in high-fat diet-fed animals. Similar phenotype was observed in obese subjects in a cohort of free-living people. This developmental bias was independent of any crosstalk between CD4 + T cells and dendritic cells and was mediated via direct exposure of CD4 + T cells to palmitate, leading to increased activation of a PI3K p110d-Akt-dependent pathway upon priming. 2017 Journal Article http://hdl.handle.net/20.500.11937/55371 10.1016/j.cmet.2017.01.008 unknown |
| spellingShingle | Mauro, C. Smith, J. Cucchi, D. Coe, D. Fu, H. Bonacina, F. Baragetti, A. Cermenati, G. Caruso, D. Mitro, N. Catapano, A. Ammirati, E. Longhi, M. Okkenhaug, K. Norata, Giuseppe Marelli-Berg, F. Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals |
| title | Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals |
| title_full | Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals |
| title_fullStr | Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals |
| title_full_unstemmed | Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals |
| title_short | Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110d-Akt-Mediated Signals |
| title_sort | obesity-induced metabolic stress leads to biased effector memory cd4+ t cell differentiation via pi3k p110d-akt-mediated signals |
| url | http://hdl.handle.net/20.500.11937/55371 |