Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes
Three-component condensation of veratrole, isobutylene oxide, and aliphatic omega-chloronitriles via the Ritter reaction leads to 1-(omega-chloroalkyl)-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesiz...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Springer
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/5503 |
| _version_ | 1848744815258238976 |
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| author | Glushkov, V. Stryapunina, O. Dolzhenko, Anton Syropyatov, B. Shklyaev, Y. |
| author_facet | Glushkov, V. Stryapunina, O. Dolzhenko, Anton Syropyatov, B. Shklyaev, Y. |
| author_sort | Glushkov, V. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Three-component condensation of veratrole, isobutylene oxide, and aliphatic omega-chloronitriles via the Ritter reaction leads to 1-(omega-chloroalkyl)-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity. |
| first_indexed | 2025-11-14T06:07:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-5503 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:07:27Z |
| publishDate | 2009 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-55032017-09-13T16:06:09Z Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes Glushkov, V. Stryapunina, O. Dolzhenko, Anton Syropyatov, B. Shklyaev, Y. Three-component condensation of veratrole, isobutylene oxide, and aliphatic omega-chloronitriles via the Ritter reaction leads to 1-(omega-chloroalkyl)-6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines, the reduction of which with NaBH4 yields benzoannelated azabicyclo[m.n.0]alkanes. The synthesized compounds have been tested for hypotensive and antiaggregant activity. 2009 Journal Article http://hdl.handle.net/20.500.11937/5503 10.1007/s11094-009-0284-1 Springer restricted |
| spellingShingle | Glushkov, V. Stryapunina, O. Dolzhenko, Anton Syropyatov, B. Shklyaev, Y. Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes |
| title | Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes |
| title_full | Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes |
| title_fullStr | Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes |
| title_full_unstemmed | Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes |
| title_short | Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes |
| title_sort | synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes |
| url | http://hdl.handle.net/20.500.11937/5503 |