Mannitol challenge testing for asthma in a community cohort of young adults
Background and objective: Mannitol challenge testing is an established tool for clinical asthma diagnosis, and can be performed outside of specialized respiratory laboratories. Despite applicability in both clinical and non-clinical populations, with different pre-test asthma probabilities, differen...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Wiley-Blackwell Publishing Asia
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/55010 |
| _version_ | 1848759524400300032 |
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| author | White, E. de Klerk, N. Hantos, Z. Priston, M. Hollams, E. James, A. Sly, P. Holt, P. Hall, Graham |
| author_facet | White, E. de Klerk, N. Hantos, Z. Priston, M. Hollams, E. James, A. Sly, P. Holt, P. Hall, Graham |
| author_sort | White, E. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background and objective: Mannitol challenge testing is an established tool for clinical asthma diagnosis, and can be performed outside of specialized respiratory laboratories. Despite applicability in both clinical and non-clinical populations, with different pre-test asthma probabilities, differences in diagnostic properties have not been well explored. This study aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort. Methods: During the 22-year follow-up of the Western Australian Pregnancy (Raine) Cohort, 772 participants (384 males) completed mannitol challenge and skin prick testing and respiratory health questionnaires, of whom 148 reporting wheeze in the past 12 months were included in a wheezing subset. Results: Responsiveness to mannitol had low sensitivity (19%) and high specificity (97%) to identify current asthma in the complete cohort, with positive and negative predictive values (PPV and NPV) of 45% and 92%, respectively. Within the wheezing subset, sensitivity (19%) and specificity (94%) remained similar, but PPV increased to 79%, and NPV decreased to 52%. Conclusion: Our findings support previously reported high specificity and good PPV for mannitol challenge testing in symptomatic wheezing populations, and highlight the need for caution when interpreting mannitol test results in non-clinical populations. |
| first_indexed | 2025-11-14T10:01:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-55010 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:01:15Z |
| publishDate | 2017 |
| publisher | Wiley-Blackwell Publishing Asia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-550102017-09-29T06:57:56Z Mannitol challenge testing for asthma in a community cohort of young adults White, E. de Klerk, N. Hantos, Z. Priston, M. Hollams, E. James, A. Sly, P. Holt, P. Hall, Graham Background and objective: Mannitol challenge testing is an established tool for clinical asthma diagnosis, and can be performed outside of specialized respiratory laboratories. Despite applicability in both clinical and non-clinical populations, with different pre-test asthma probabilities, differences in diagnostic properties have not been well explored. This study aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort. Methods: During the 22-year follow-up of the Western Australian Pregnancy (Raine) Cohort, 772 participants (384 males) completed mannitol challenge and skin prick testing and respiratory health questionnaires, of whom 148 reporting wheeze in the past 12 months were included in a wheezing subset. Results: Responsiveness to mannitol had low sensitivity (19%) and high specificity (97%) to identify current asthma in the complete cohort, with positive and negative predictive values (PPV and NPV) of 45% and 92%, respectively. Within the wheezing subset, sensitivity (19%) and specificity (94%) remained similar, but PPV increased to 79%, and NPV decreased to 52%. Conclusion: Our findings support previously reported high specificity and good PPV for mannitol challenge testing in symptomatic wheezing populations, and highlight the need for caution when interpreting mannitol test results in non-clinical populations. 2017 Journal Article http://hdl.handle.net/20.500.11937/55010 10.1111/resp.12955 Wiley-Blackwell Publishing Asia restricted |
| spellingShingle | White, E. de Klerk, N. Hantos, Z. Priston, M. Hollams, E. James, A. Sly, P. Holt, P. Hall, Graham Mannitol challenge testing for asthma in a community cohort of young adults |
| title | Mannitol challenge testing for asthma in a community cohort of young adults |
| title_full | Mannitol challenge testing for asthma in a community cohort of young adults |
| title_fullStr | Mannitol challenge testing for asthma in a community cohort of young adults |
| title_full_unstemmed | Mannitol challenge testing for asthma in a community cohort of young adults |
| title_short | Mannitol challenge testing for asthma in a community cohort of young adults |
| title_sort | mannitol challenge testing for asthma in a community cohort of young adults |
| url | http://hdl.handle.net/20.500.11937/55010 |