Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years
Background: The forced oscillation technique (FOT) can be used in children as young as 2 years of age and in those unable to perform routine spirometry. There is limited information on changes in FOT outcomes in healthy children beyond the preschool years and the level of bronchodilator responsivene...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal Article |
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Wiley-Liss, Inc
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/54962 |
| _version_ | 1848759508819509248 |
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| author | Calogero, C. Simpson, S. Lombardi, E. Parri, N. Cuomo, B. Palumbo, M. De Martino, M. Shackleton, C. Verheggen, M. Gavidia, T. Franklin, P. Kusel, M. Park, J. Sly, P. Hall, Graham |
| author_facet | Calogero, C. Simpson, S. Lombardi, E. Parri, N. Cuomo, B. Palumbo, M. De Martino, M. Shackleton, C. Verheggen, M. Gavidia, T. Franklin, P. Kusel, M. Park, J. Sly, P. Hall, Graham |
| author_sort | Calogero, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: The forced oscillation technique (FOT) can be used in children as young as 2 years of age and in those unable to perform routine spirometry. There is limited information on changes in FOT outcomes in healthy children beyond the preschool years and the level of bronchodilator responsiveness (BDR) in healthy children. We aimed to create reference ranges for respiratory impedance outcomes collated from multiple centers. Outcomes included respiratory system resistance (Rrs) and reactance (Xrs), resonant frequency (Fres), frequency dependence of Rrs (Fdep), and the area under the reactance curve (AX). We also aimed to define the physiological effects of bronchodilators in a large population of healthy children using the FOT. Methods: Respiratory impedance was measured in 760 healthy children, aged 2–13 years, from Australia and Italy. Stepwise linear regression identified anthropometric predictors of transformed Rrs and Xrs at 6, 8, and 10 Hz, Fres, Fdep, and AX. Bronchodilator response (BDR) was assessed in 508 children after 200 µg of inhaled salbutamol. Results: Regression analysis showed that Rrs, Xrs, and AX outcomes were dependent on height and sex. The BDR cut-offs by absolute change in Rrs8, Xrs8, and AX were −2.74 hPa s L−1, 1.93 hPa s L−1, and −33 hPa s L−1, respectively. These corresponded to relative and Z-score changes of −32%; −1.85 for Rrs8, 65%; 1.95 for Xrs8, and −82%; −2.04 for AX. Conclusions: We have established generalizable reference ranges for respiratory impedance and defined cut-offs for a positive bronchodilator response using the FOT in healthy children. |
| first_indexed | 2025-11-14T10:01:00Z |
| format | Journal Article |
| id | curtin-20.500.11937-54962 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:01:00Z |
| publishDate | 2013 |
| publisher | Wiley-Liss, Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-549622017-09-29T06:25:10Z Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years Calogero, C. Simpson, S. Lombardi, E. Parri, N. Cuomo, B. Palumbo, M. De Martino, M. Shackleton, C. Verheggen, M. Gavidia, T. Franklin, P. Kusel, M. Park, J. Sly, P. Hall, Graham Background: The forced oscillation technique (FOT) can be used in children as young as 2 years of age and in those unable to perform routine spirometry. There is limited information on changes in FOT outcomes in healthy children beyond the preschool years and the level of bronchodilator responsiveness (BDR) in healthy children. We aimed to create reference ranges for respiratory impedance outcomes collated from multiple centers. Outcomes included respiratory system resistance (Rrs) and reactance (Xrs), resonant frequency (Fres), frequency dependence of Rrs (Fdep), and the area under the reactance curve (AX). We also aimed to define the physiological effects of bronchodilators in a large population of healthy children using the FOT. Methods: Respiratory impedance was measured in 760 healthy children, aged 2–13 years, from Australia and Italy. Stepwise linear regression identified anthropometric predictors of transformed Rrs and Xrs at 6, 8, and 10 Hz, Fres, Fdep, and AX. Bronchodilator response (BDR) was assessed in 508 children after 200 µg of inhaled salbutamol. Results: Regression analysis showed that Rrs, Xrs, and AX outcomes were dependent on height and sex. The BDR cut-offs by absolute change in Rrs8, Xrs8, and AX were −2.74 hPa s L−1, 1.93 hPa s L−1, and −33 hPa s L−1, respectively. These corresponded to relative and Z-score changes of −32%; −1.85 for Rrs8, 65%; 1.95 for Xrs8, and −82%; −2.04 for AX. Conclusions: We have established generalizable reference ranges for respiratory impedance and defined cut-offs for a positive bronchodilator response using the FOT in healthy children. 2013 Journal Article http://hdl.handle.net/20.500.11937/54962 10.1002/ppul.22699 Wiley-Liss, Inc restricted |
| spellingShingle | Calogero, C. Simpson, S. Lombardi, E. Parri, N. Cuomo, B. Palumbo, M. De Martino, M. Shackleton, C. Verheggen, M. Gavidia, T. Franklin, P. Kusel, M. Park, J. Sly, P. Hall, Graham Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years |
| title | Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years |
| title_full | Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years |
| title_fullStr | Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years |
| title_full_unstemmed | Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years |
| title_short | Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years |
| title_sort | respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years |
| url | http://hdl.handle.net/20.500.11937/54962 |