Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness
Rationale: Lower respiratory tract illness is a major cause of childhood morbidity and mortality. It is unknown whether infants are predisposed to illness because of impaired lung function or whether respiratory illness reduces lung function. Objectives: To investigate the impact of early life expos...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
American Thoracic Society
2017
|
| Online Access: | http://hdl.handle.net/20.500.11937/54951 |
| _version_ | 1848759505636032512 |
|---|---|
| author | Gray, D. Turkovic, L. Willemse, L. Visagie, A. Vanker, A. Stein, D. Sly, P. Hall, Graham Zar, H. |
| author_facet | Gray, D. Turkovic, L. Willemse, L. Visagie, A. Vanker, A. Stein, D. Sly, P. Hall, Graham Zar, H. |
| author_sort | Gray, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Rationale: Lower respiratory tract illness is a major cause of childhood morbidity and mortality. It is unknown whether infants are predisposed to illness because of impaired lung function or whether respiratory illness reduces lung function. Objectives: To investigate the impact of early life exposures, including lower respiratory tract illness, on lung function during infancy. Methods: Infants enrolled in the Drakenstein child health study had lung function at 6 weeks and 1 year. Testing during quiet natural sleep included tidal breathing, exhaled nitric oxide, and multiple breath washout measures. Risk factors for impaired lung health were collected longitudinally. Lower respiratory tract illness surveillance was performed and any episode investigated. Measurements and Main Results: Lung function was tested in 648 children at 1 year. One hundred and fifty (29%) infants had a lower respiratory tract illness during the first year of life. Lower respiratory tract illness was independently associated with increased respiratory rate (4%; 95% confidence interval [CI] , 1.01-1.08; P = 0.02). Repeat episodes further increased respiratory rate (3%; 95% CI, 1.01-1.05; P = 0.004), decreased tidal volume (21.7 ml; 95% CI, 23.3 to 20.2; P = 0.03), and increased the lung clearance index (0.13 turnovers; 95% CI, 0.04-0.22; P = 0.006) compared with infants without illness. Tobacco smoke exposure, lung function at 6 weeks, infant growth, and prematurity were other independent predictors of lung function at 1 year. Conclusions: Early life lower respiratory tract illness impairs lung function at 1 year, independent of baseline lung function. Preventing early life lower respiratory tract illness is important to optimize lung function and promote respiratory health in childhood. |
| first_indexed | 2025-11-14T10:00:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-54951 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:00:57Z |
| publishDate | 2017 |
| publisher | American Thoracic Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-549512018-03-29T09:09:37Z Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness Gray, D. Turkovic, L. Willemse, L. Visagie, A. Vanker, A. Stein, D. Sly, P. Hall, Graham Zar, H. Rationale: Lower respiratory tract illness is a major cause of childhood morbidity and mortality. It is unknown whether infants are predisposed to illness because of impaired lung function or whether respiratory illness reduces lung function. Objectives: To investigate the impact of early life exposures, including lower respiratory tract illness, on lung function during infancy. Methods: Infants enrolled in the Drakenstein child health study had lung function at 6 weeks and 1 year. Testing during quiet natural sleep included tidal breathing, exhaled nitric oxide, and multiple breath washout measures. Risk factors for impaired lung health were collected longitudinally. Lower respiratory tract illness surveillance was performed and any episode investigated. Measurements and Main Results: Lung function was tested in 648 children at 1 year. One hundred and fifty (29%) infants had a lower respiratory tract illness during the first year of life. Lower respiratory tract illness was independently associated with increased respiratory rate (4%; 95% confidence interval [CI] , 1.01-1.08; P = 0.02). Repeat episodes further increased respiratory rate (3%; 95% CI, 1.01-1.05; P = 0.004), decreased tidal volume (21.7 ml; 95% CI, 23.3 to 20.2; P = 0.03), and increased the lung clearance index (0.13 turnovers; 95% CI, 0.04-0.22; P = 0.006) compared with infants without illness. Tobacco smoke exposure, lung function at 6 weeks, infant growth, and prematurity were other independent predictors of lung function at 1 year. Conclusions: Early life lower respiratory tract illness impairs lung function at 1 year, independent of baseline lung function. Preventing early life lower respiratory tract illness is important to optimize lung function and promote respiratory health in childhood. 2017 Journal Article http://hdl.handle.net/20.500.11937/54951 10.1164/rccm.201601-0188OC American Thoracic Society restricted |
| spellingShingle | Gray, D. Turkovic, L. Willemse, L. Visagie, A. Vanker, A. Stein, D. Sly, P. Hall, Graham Zar, H. Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness |
| title | Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness |
| title_full | Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness |
| title_fullStr | Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness |
| title_full_unstemmed | Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness |
| title_short | Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness |
| title_sort | lung function in african infants in the drakenstein child health study impact of lower respiratory tract illness |
| url | http://hdl.handle.net/20.500.11937/54951 |