Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients
This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290 treatment cycles for women in the poorest AFC category, ≤4 follicles (group E), the LBR was the lo...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/54820 |
| _version_ | 1848759470352498688 |
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| author | Mustafa, K. Keane, Kevin Walz, N. Mitrovic, K. Hinchliffe, P. Yovich, John |
| author_facet | Mustafa, K. Keane, Kevin Walz, N. Mitrovic, K. Hinchliffe, P. Yovich, John |
| author_sort | Mustafa, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290 treatment cycles for women in the poorest AFC category, ≤4 follicles (group E), the LBR was the lowest at 10.7%. The pregnancy loss rate (PLR) significantly increased with poorer AFC categories, from 21.8% in AFC group A (≥20 follicles), to 54.4% in AFC group E (p < 0.0001). This trend was repeated with advancing age, from 21.6% for younger women ( < 35 years), to 32.9, 48.5 and 100% for ages 35–39, 40–44 and ≥45 years, respectively (p < 0.0001). However, LBR within the specific AFC group E cohort was also age-dependent and decreased significantly from 30.0% for <35 years old, to 13.3, 3.9 and 0% for patients aged 35–39, 40–44 and ≥45 years, respectively. Most, importantly, LBR rates within these age groups were not dependent on the number of IVF attempts (1st, 2nd, 3rd or ≥4 cycles), which indicated that cycle number should not be the primary deciding factor for cessation of IVF treatment in responding women <45years old. |
| first_indexed | 2025-11-14T10:00:24Z |
| format | Journal Article |
| id | curtin-20.500.11937-54820 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:00:24Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-548202017-10-31T01:21:10Z Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients Mustafa, K. Keane, Kevin Walz, N. Mitrovic, K. Hinchliffe, P. Yovich, John This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290 treatment cycles for women in the poorest AFC category, ≤4 follicles (group E), the LBR was the lowest at 10.7%. The pregnancy loss rate (PLR) significantly increased with poorer AFC categories, from 21.8% in AFC group A (≥20 follicles), to 54.4% in AFC group E (p < 0.0001). This trend was repeated with advancing age, from 21.6% for younger women ( < 35 years), to 32.9, 48.5 and 100% for ages 35–39, 40–44 and ≥45 years, respectively (p < 0.0001). However, LBR within the specific AFC group E cohort was also age-dependent and decreased significantly from 30.0% for <35 years old, to 13.3, 3.9 and 0% for patients aged 35–39, 40–44 and ≥45 years, respectively. Most, importantly, LBR rates within these age groups were not dependent on the number of IVF attempts (1st, 2nd, 3rd or ≥4 cycles), which indicated that cycle number should not be the primary deciding factor for cessation of IVF treatment in responding women <45years old. 2017 Journal Article http://hdl.handle.net/20.500.11937/54820 10.1016/j.repbio.2016.11.004 restricted |
| spellingShingle | Mustafa, K. Keane, Kevin Walz, N. Mitrovic, K. Hinchliffe, P. Yovich, John Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients |
| title | Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients |
| title_full | Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients |
| title_fullStr | Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients |
| title_full_unstemmed | Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients |
| title_short | Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients |
| title_sort | live birth rates are satisfactory following multiple ivf treatment cycles in poor prognosis patients |
| url | http://hdl.handle.net/20.500.11937/54820 |