Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments
The purpose of this study was to determine the relationship between left coronary bifurcation angle and significant coronary stenosis with use of coronary CT angiography (CCTA)-generated computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of coronary lumen stenosis with in...
| Main Authors: | , |
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| Format: | Journal Article |
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Future Medicine Ltd
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/54790 |
| _version_ | 1848759461723766784 |
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| author | Sun, Zhonghua Chaichana, T. |
| author_facet | Sun, Zhonghua Chaichana, T. |
| author_sort | Sun, Zhonghua |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The purpose of this study was to determine the relationship between left coronary bifurcation angle and significant coronary stenosis with use of coronary CT angiography (CCTA)-generated computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of coronary lumen stenosis with invasive coronary angiography (ICA) as the reference method. Eleven patients with calcified plaques at the left coronary artery tree who underwent CCTA and ICA examinations were included in the study. CFD simulation of left coronary models was performed to analyse hemodynamic changes including wall shear stress, wall pressure and flow velocity. The mean bifurcation angle was measured 83.3 ± 17.1° and 83.3 ± 17.0° on CCTA and ICA, respectively, with no significant difference (p=0.99). Of 15 significant stenosis at left anterior descending (LAD) and left circumflex (LCx) on CCTA, only 3 of them were confirmed to be > 50% stenosis on ICA. Wall shear stress was noted to increase in the LAD and LCx models with significant stenosis and wider angulation (> 80°), but remained no change in most of the other coronary models with no significant stenosis and narrower angulation. Wall pressured was decreased at the significant stenotic lesions, while flow velocity was increased with flow turbulence at the post-stenotic sites. This study further clarifies the direct correlation between left coronary bifurcation angle and significant stenosis, with angulation measurement being more accurate than lumen assessment for diagnosing significant stenosis. |
| first_indexed | 2025-11-14T10:00:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-54790 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:00:15Z |
| publishDate | 2016 |
| publisher | Future Medicine Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-547902017-10-31T05:47:33Z Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments Sun, Zhonghua Chaichana, T. The purpose of this study was to determine the relationship between left coronary bifurcation angle and significant coronary stenosis with use of coronary CT angiography (CCTA)-generated computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of coronary lumen stenosis with invasive coronary angiography (ICA) as the reference method. Eleven patients with calcified plaques at the left coronary artery tree who underwent CCTA and ICA examinations were included in the study. CFD simulation of left coronary models was performed to analyse hemodynamic changes including wall shear stress, wall pressure and flow velocity. The mean bifurcation angle was measured 83.3 ± 17.1° and 83.3 ± 17.0° on CCTA and ICA, respectively, with no significant difference (p=0.99). Of 15 significant stenosis at left anterior descending (LAD) and left circumflex (LCx) on CCTA, only 3 of them were confirmed to be > 50% stenosis on ICA. Wall shear stress was noted to increase in the LAD and LCx models with significant stenosis and wider angulation (> 80°), but remained no change in most of the other coronary models with no significant stenosis and narrower angulation. Wall pressured was decreased at the significant stenotic lesions, while flow velocity was increased with flow turbulence at the post-stenotic sites. This study further clarifies the direct correlation between left coronary bifurcation angle and significant stenosis, with angulation measurement being more accurate than lumen assessment for diagnosing significant stenosis. 2016 Journal Article http://hdl.handle.net/20.500.11937/54790 10.4172/Interventional-Cardiology.1000543 http://creativecommons.org/licenses/by/4.0/ Future Medicine Ltd fulltext |
| spellingShingle | Sun, Zhonghua Chaichana, T. Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments |
| title | Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments |
| title_full | Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments |
| title_fullStr | Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments |
| title_full_unstemmed | Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments |
| title_short | Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments |
| title_sort | computational fluid dynamic analysis of calcified coronary plaques: correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments |
| url | http://hdl.handle.net/20.500.11937/54790 |