Weight loss and carotid intima-media thickness—a meta-analysis
Objective: Obesity is a risk factor for clinical cardiovascular disease, putatively via increased burden of atherosclerosis. It remains contentious as to whether weight loss in people with obesity is accompanied by a reduction in intima-media thickness, a noninvasive marker of subclinical atheroscle...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/54765 |
| _version_ | 1848759455134515200 |
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| author | Skilton, M. Yeo, S. Ne, J. Celermajer, D. Caterson, I. Lee, Crystal |
| author_facet | Skilton, M. Yeo, S. Ne, J. Celermajer, D. Caterson, I. Lee, Crystal |
| author_sort | Skilton, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: Obesity is a risk factor for clinical cardiovascular disease, putatively via increased burden of atherosclerosis. It remains contentious as to whether weight loss in people with obesity is accompanied by a reduction in intima-media thickness, a noninvasive marker of subclinical atherosclerosis, consistent with a lowering of risk of cardiovascular events. Methods: A systematic literature search was performed to identify all surgical and nonsurgical weight loss interventions that reported intima-media thickness. A meta-analysis was undertaken to obtain pooled estimates for change in intima-media thickness. Results: From the 3,197 articles screened, 9 studies were included in the meta-analysis, with a total of 393 participants who lost an average of 16 kg (95% CI 9.4–22.5) of body weight over an average follow-up of 20 months. The pooled mean change in carotid intima-media thickness was -0.03 mm (95% CI -0.05 to -0.01), which was similar between surgical and nonsurgical interventions. Conclusions: In people with obesity, weight loss was associated with a reduction in carotid intima-media thickness, consistent with a lowering in risk of cardiovascular events. |
| first_indexed | 2025-11-14T10:00:09Z |
| format | Journal Article |
| id | curtin-20.500.11937-54765 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:00:09Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-547652017-09-28T07:33:03Z Weight loss and carotid intima-media thickness—a meta-analysis Skilton, M. Yeo, S. Ne, J. Celermajer, D. Caterson, I. Lee, Crystal Objective: Obesity is a risk factor for clinical cardiovascular disease, putatively via increased burden of atherosclerosis. It remains contentious as to whether weight loss in people with obesity is accompanied by a reduction in intima-media thickness, a noninvasive marker of subclinical atherosclerosis, consistent with a lowering of risk of cardiovascular events. Methods: A systematic literature search was performed to identify all surgical and nonsurgical weight loss interventions that reported intima-media thickness. A meta-analysis was undertaken to obtain pooled estimates for change in intima-media thickness. Results: From the 3,197 articles screened, 9 studies were included in the meta-analysis, with a total of 393 participants who lost an average of 16 kg (95% CI 9.4–22.5) of body weight over an average follow-up of 20 months. The pooled mean change in carotid intima-media thickness was -0.03 mm (95% CI -0.05 to -0.01), which was similar between surgical and nonsurgical interventions. Conclusions: In people with obesity, weight loss was associated with a reduction in carotid intima-media thickness, consistent with a lowering in risk of cardiovascular events. 2017 Journal Article http://hdl.handle.net/20.500.11937/54765 10.1002/oby.21732 Nature Publishing Group restricted |
| spellingShingle | Skilton, M. Yeo, S. Ne, J. Celermajer, D. Caterson, I. Lee, Crystal Weight loss and carotid intima-media thickness—a meta-analysis |
| title | Weight loss and carotid intima-media thickness—a meta-analysis |
| title_full | Weight loss and carotid intima-media thickness—a meta-analysis |
| title_fullStr | Weight loss and carotid intima-media thickness—a meta-analysis |
| title_full_unstemmed | Weight loss and carotid intima-media thickness—a meta-analysis |
| title_short | Weight loss and carotid intima-media thickness—a meta-analysis |
| title_sort | weight loss and carotid intima-media thickness—a meta-analysis |
| url | http://hdl.handle.net/20.500.11937/54765 |