Respiratory function and symptoms in young preterm children in the contemporary era
Objective: To determine the relationships between respiratory symptoms, lung function, and neonatal events in young preterm children. Methods: Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non-BPD, and healthy term controls were studied. Lung function w...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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Wiley-Liss, Inc
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/54668 |
| _version_ | 1848759429567086592 |
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| author | Verheggen, M. Wilson, A. Pillow, J. Stick, S. Hall, Graham |
| author_facet | Verheggen, M. Wilson, A. Pillow, J. Stick, S. Hall, Graham |
| author_sort | Verheggen, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: To determine the relationships between respiratory symptoms, lung function, and neonatal events in young preterm children. Methods: Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non-BPD, and healthy term controls were studied. Lung function was measured by forced oscillation technique (respiratory resistance [Rrs] and reactance [Xrs]) and spirometry. Respiratory symptom questionnaires were administered. Results: One hundred and fifty children (74 BPD, 44 non-BPD, 32 controls) 4–8 years were studied. Lung function (median Z-score [10,90th centile]) was significantly impaired in preterm children compared to controls for FVC (0.00 [-1.18, 1.76], 0.69 [-0.17,1.86]), FEV1 (-0.44 [-1.94, 1.11], 0.49 [-0.83, 2.51]), Xrs (-1.26 [-3.31, 0.11], -0.11 [-0.97, 0.73]), and Rrs (0.55 [-0.48, 1.82], 0.28 [-0.99, 0.96]). Only Xrs differed between the BPD and non-BPD (-1.51 [-3.59, -0.41], -0.89 [-2.64, 0.52]). The prevalence of recent respiratory symptoms (range: 32–36%) did not differ between BPD and non-BPD children. Supplemental O2 in hospital was positively associated with worsening Xrs and FEV1. Conclusion: Preterm children have worse lung function than healthy controls. Only respiratory reactance differentiated between preterm children with and without BPD and was influenced by days of O2 in hospital. Pediatr Pulmonol. 2016;51:1347–1355. |
| first_indexed | 2025-11-14T09:59:45Z |
| format | Journal Article |
| id | curtin-20.500.11937-54668 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:59:45Z |
| publishDate | 2016 |
| publisher | Wiley-Liss, Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-546682017-09-29T07:07:32Z Respiratory function and symptoms in young preterm children in the contemporary era Verheggen, M. Wilson, A. Pillow, J. Stick, S. Hall, Graham Objective: To determine the relationships between respiratory symptoms, lung function, and neonatal events in young preterm children. Methods: Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non-BPD, and healthy term controls were studied. Lung function was measured by forced oscillation technique (respiratory resistance [Rrs] and reactance [Xrs]) and spirometry. Respiratory symptom questionnaires were administered. Results: One hundred and fifty children (74 BPD, 44 non-BPD, 32 controls) 4–8 years were studied. Lung function (median Z-score [10,90th centile]) was significantly impaired in preterm children compared to controls for FVC (0.00 [-1.18, 1.76], 0.69 [-0.17,1.86]), FEV1 (-0.44 [-1.94, 1.11], 0.49 [-0.83, 2.51]), Xrs (-1.26 [-3.31, 0.11], -0.11 [-0.97, 0.73]), and Rrs (0.55 [-0.48, 1.82], 0.28 [-0.99, 0.96]). Only Xrs differed between the BPD and non-BPD (-1.51 [-3.59, -0.41], -0.89 [-2.64, 0.52]). The prevalence of recent respiratory symptoms (range: 32–36%) did not differ between BPD and non-BPD children. Supplemental O2 in hospital was positively associated with worsening Xrs and FEV1. Conclusion: Preterm children have worse lung function than healthy controls. Only respiratory reactance differentiated between preterm children with and without BPD and was influenced by days of O2 in hospital. Pediatr Pulmonol. 2016;51:1347–1355. 2016 Journal Article http://hdl.handle.net/20.500.11937/54668 10.1002/ppul.23487 Wiley-Liss, Inc restricted |
| spellingShingle | Verheggen, M. Wilson, A. Pillow, J. Stick, S. Hall, Graham Respiratory function and symptoms in young preterm children in the contemporary era |
| title | Respiratory function and symptoms in young preterm children in the contemporary era |
| title_full | Respiratory function and symptoms in young preterm children in the contemporary era |
| title_fullStr | Respiratory function and symptoms in young preterm children in the contemporary era |
| title_full_unstemmed | Respiratory function and symptoms in young preterm children in the contemporary era |
| title_short | Respiratory function and symptoms in young preterm children in the contemporary era |
| title_sort | respiratory function and symptoms in young preterm children in the contemporary era |
| url | http://hdl.handle.net/20.500.11937/54668 |