Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10
Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM di...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Inc.
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/54482 |
| _version_ | 1848759382110633984 |
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| author | Halstrom, S. Thomson, R. Goullee, H. Baltic, S. Allcock, R. Temple, S. Price, Patricia |
| author_facet | Halstrom, S. Thomson, R. Goullee, H. Baltic, S. Allcock, R. Temple, S. Price, Patricia |
| author_sort | Halstrom, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896. |
| first_indexed | 2025-11-14T09:58:59Z |
| format | Journal Article |
| id | curtin-20.500.11937-54482 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:58:59Z |
| publishDate | 2017 |
| publisher | Elsevier Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-544822018-02-05T23:53:41Z Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10 Halstrom, S. Thomson, R. Goullee, H. Baltic, S. Allcock, R. Temple, S. Price, Patricia Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896. 2017 Journal Article http://hdl.handle.net/20.500.11937/54482 10.1016/j.humimm.2017.02.001 Elsevier Inc. fulltext |
| spellingShingle | Halstrom, S. Thomson, R. Goullee, H. Baltic, S. Allcock, R. Temple, S. Price, Patricia Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10 |
| title | Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10 |
| title_full | Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10 |
| title_fullStr | Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10 |
| title_full_unstemmed | Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10 |
| title_short | Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10 |
| title_sort | susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in il10 |
| url | http://hdl.handle.net/20.500.11937/54482 |