Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

There is a critical need for blood pressure-lowering strategies that have greater efficacy and minimal side effects. Low-dose combinations hold promise in this regard, but there are few data on very-low-dose therapy. We, therefore, conducted a systematic review and meta-analysis of randomized contro...

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Main Authors: Bennett, A., Chow, C., Chou, M., Dehbi, H., Webster, R., Salam, A., Patel, A., Neal, B., Peiris, D., Thakkar, J., Chalmers, J., Nelson, M., Reid, Christopher, Hillis, G., Woodward, M., Hilmer, S., Usherwood, T., Thom, S., Rodgers, A.
Format: Journal Article
Published: American Heart Association 2017
Online Access:http://hdl.handle.net/20.500.11937/54481
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author Bennett, A.
Chow, C.
Chou, M.
Dehbi, H.
Webster, R.
Salam, A.
Patel, A.
Neal, B.
Peiris, D.
Thakkar, J.
Chalmers, J.
Nelson, M.
Reid, Christopher
Hillis, G.
Woodward, M.
Hilmer, S.
Usherwood, T.
Thom, S.
Rodgers, A.
author_facet Bennett, A.
Chow, C.
Chou, M.
Dehbi, H.
Webster, R.
Salam, A.
Patel, A.
Neal, B.
Peiris, D.
Thakkar, J.
Chalmers, J.
Nelson, M.
Reid, Christopher
Hillis, G.
Woodward, M.
Hilmer, S.
Usherwood, T.
Thom, S.
Rodgers, A.
author_sort Bennett, A.
building Curtin Institutional Repository
collection Online Access
description There is a critical need for blood pressure-lowering strategies that have greater efficacy and minimal side effects. Low-dose combinations hold promise in this regard, but there are few data on very-low-dose therapy. We, therefore, conducted a systematic review and meta-analysis of randomized controlled trials with at least one quarter-dose and one placebo and standard-dose monotherapy arm. A search was conducted of Medline, Embase, Cochrane Registry, Food and Drug Administration, and European Medicinal Agency websites. Data on blood pressure and adverse events were pooled using a fixed-effect model, and bias was assessed using Cochrane risk of bias. The review included 42 trials involving 20 284 participants. Thirty-six comparisons evaluated quarter-dose with placebo and indicated a blood pressure reduction of -4.7/-2.4 mm Hg (P < 0.001). Six comparisons were of dual quarter-dose therapy versus placebo, observing a -6.7/ -4.4 mm Hg (P < 0.001) blood pressure reduction. There were no trials of triple quarter-dose combination versus placebo, but one quadruple quarter-dose study observed a blood pressure reduction of -22.4/-13.1 mm Hg versus placebo (P < 0.001). Compared with standard-dose monotherapy, the blood pressure differences achieved by single (37 comparisons), dual (7 comparisons), and quadruple (1 trial) quarter-dose combinations were +3.7/+2.6 (P < 0.001), +1.3/-0.3 (NS), and -13.1/-7.9 (P < 0.001) mm Hg, respectively. In terms of adverse events, single and dual quarter-dose therapy was not significantly different from placebo and had significantly fewer adverse events compared with standard-dose monotherapy. Quarter-dose combinations could provide improvements in efficacy and tolerability of blood pressure-lowering therapy.
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spelling curtin-20.500.11937-544812017-09-20T01:10:42Z Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Bennett, A. Chow, C. Chou, M. Dehbi, H. Webster, R. Salam, A. Patel, A. Neal, B. Peiris, D. Thakkar, J. Chalmers, J. Nelson, M. Reid, Christopher Hillis, G. Woodward, M. Hilmer, S. Usherwood, T. Thom, S. Rodgers, A. There is a critical need for blood pressure-lowering strategies that have greater efficacy and minimal side effects. Low-dose combinations hold promise in this regard, but there are few data on very-low-dose therapy. We, therefore, conducted a systematic review and meta-analysis of randomized controlled trials with at least one quarter-dose and one placebo and standard-dose monotherapy arm. A search was conducted of Medline, Embase, Cochrane Registry, Food and Drug Administration, and European Medicinal Agency websites. Data on blood pressure and adverse events were pooled using a fixed-effect model, and bias was assessed using Cochrane risk of bias. The review included 42 trials involving 20 284 participants. Thirty-six comparisons evaluated quarter-dose with placebo and indicated a blood pressure reduction of -4.7/-2.4 mm Hg (P < 0.001). Six comparisons were of dual quarter-dose therapy versus placebo, observing a -6.7/ -4.4 mm Hg (P < 0.001) blood pressure reduction. There were no trials of triple quarter-dose combination versus placebo, but one quadruple quarter-dose study observed a blood pressure reduction of -22.4/-13.1 mm Hg versus placebo (P < 0.001). Compared with standard-dose monotherapy, the blood pressure differences achieved by single (37 comparisons), dual (7 comparisons), and quadruple (1 trial) quarter-dose combinations were +3.7/+2.6 (P < 0.001), +1.3/-0.3 (NS), and -13.1/-7.9 (P < 0.001) mm Hg, respectively. In terms of adverse events, single and dual quarter-dose therapy was not significantly different from placebo and had significantly fewer adverse events compared with standard-dose monotherapy. Quarter-dose combinations could provide improvements in efficacy and tolerability of blood pressure-lowering therapy. 2017 Journal Article http://hdl.handle.net/20.500.11937/54481 10.1161/HYPERTENSIONAHA.117.09202 American Heart Association restricted
spellingShingle Bennett, A.
Chow, C.
Chou, M.
Dehbi, H.
Webster, R.
Salam, A.
Patel, A.
Neal, B.
Peiris, D.
Thakkar, J.
Chalmers, J.
Nelson, M.
Reid, Christopher
Hillis, G.
Woodward, M.
Hilmer, S.
Usherwood, T.
Thom, S.
Rodgers, A.
Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short Efficacy and Safety of Quarter-Dose Blood Pressure-Lowering Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort efficacy and safety of quarter-dose blood pressure-lowering agents: a systematic review and meta-analysis of randomized controlled trials
url http://hdl.handle.net/20.500.11937/54481