The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy
Antibody responses have not been fully characterised in chronically HIV/HCV patients receiving antiretroviral therapy (ART). Seventeen HIV/HCV patients receiving ART were followed for a median (range) interval of 597 (186–766) weeks. Prior to ART, HIV/HCV patients had lower levels of antibodies reac...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Academic Press
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/54437 |
| _version_ | 1848759371297718272 |
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| author | Lee, S. Laiman, A. French, M. Flexman, J. Watson, M. Price, Patricia |
| author_facet | Lee, S. Laiman, A. French, M. Flexman, J. Watson, M. Price, Patricia |
| author_sort | Lee, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Antibody responses have not been fully characterised in chronically HIV/HCV patients receiving antiretroviral therapy (ART). Seventeen HIV/HCV patients receiving ART were followed for a median (range) interval of 597 (186–766) weeks. Prior to ART, HIV/HCV patients had lower levels of antibodies reactive with HCV core and JFH-1, and lower genotype cross-reactive neutralising antibodies (nAb) titres, than HCV patients. Levels of JFH-1 reactive antibody increased on ART, irrespective of CD4+ T-cell counts or changes in serum ALT levels. The appearance of nAb coincided with control of HCV viral replication in five HIV/HCV patients. In other patients, HCV viral loads remained elevated despite nAb responses. Sustained virological responses following HCV therapy were associated with reduced antibody responses to JFH-1 and core but elevated responses to non-structural proteins. We conclude that nAb responses alone may fail to clear HCV, but contribute to control of viral replication in some HIV/HCV patients responding to ART. |
| first_indexed | 2025-11-14T09:58:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-54437 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:58:49Z |
| publishDate | 2017 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-544372018-03-16T03:07:39Z The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy Lee, S. Laiman, A. French, M. Flexman, J. Watson, M. Price, Patricia Antibody responses have not been fully characterised in chronically HIV/HCV patients receiving antiretroviral therapy (ART). Seventeen HIV/HCV patients receiving ART were followed for a median (range) interval of 597 (186–766) weeks. Prior to ART, HIV/HCV patients had lower levels of antibodies reactive with HCV core and JFH-1, and lower genotype cross-reactive neutralising antibodies (nAb) titres, than HCV patients. Levels of JFH-1 reactive antibody increased on ART, irrespective of CD4+ T-cell counts or changes in serum ALT levels. The appearance of nAb coincided with control of HCV viral replication in five HIV/HCV patients. In other patients, HCV viral loads remained elevated despite nAb responses. Sustained virological responses following HCV therapy were associated with reduced antibody responses to JFH-1 and core but elevated responses to non-structural proteins. We conclude that nAb responses alone may fail to clear HCV, but contribute to control of viral replication in some HIV/HCV patients responding to ART. 2017 Journal Article http://hdl.handle.net/20.500.11937/54437 10.1016/j.clim.2017.03.005 Academic Press fulltext |
| spellingShingle | Lee, S. Laiman, A. French, M. Flexman, J. Watson, M. Price, Patricia The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy |
| title | The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy |
| title_full | The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy |
| title_fullStr | The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy |
| title_full_unstemmed | The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy |
| title_short | The dynamics of HCV-specific antibody responses in HIV/HCV patients on long-term antiretroviral therapy |
| title_sort | dynamics of hcv-specific antibody responses in hiv/hcv patients on long-term antiretroviral therapy |
| url | http://hdl.handle.net/20.500.11937/54437 |