Synthesis, Characterization and Biodistribution Studies of 125I-Radioiodinated di-PEGylated Bone Targeting Salmon Calcitonin Analogue in Healthy Rats

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Synthesis, Characterization and Biodistribution Studies of 125I-Radioiodinated di-PEGylated Bone Targeting Salmon Calcitonin Analogue in Healthy Rats

Purpose: The objective of this study was to prepare a bisphosphonate (BP) mediated bone targeting di-PEGylated salmon calcitonin analogue sCT-2(PEG-BP) as a novel bone targeting pharmaceutical. Methods: HPLC was used for isolation of sCT-2(PEG-BP) from the reaction mixture, followed by determination...

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Bibliographic Details
Main Authors:	Yang, Y., Bhandari, K., Panahifar, A., Doschak, Michael
Format:	Journal Article
Published:	AAPS 2013
Subjects:	HPLC osteoporosis radio-iodination sCT-2(PEG-BP) biodistribution
Online Access:	http://hdl.handle.net/20.500.11937/5437

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