Event-Based control of depth of hypnosis in anesthesia
Background and Objective: In this paper, we propose the use of an event-based control strategy for the closed-loop control of the depth of hypnosis in anesthesia by using propofol administration and the bispectral index as a controlled variable. Methods: A new event generator with high noise-filteri...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/54189 |
| _version_ | 1848759306658250752 |
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| author | Merigo, L. Beschi, M. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. |
| author_facet | Merigo, L. Beschi, M. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. |
| author_sort | Merigo, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background and Objective: In this paper, we propose the use of an event-based control strategy for the closed-loop control of the depth of hypnosis in anesthesia by using propofol administration and the bispectral index as a controlled variable. Methods: A new event generator with high noise-filtering properties is employed in addition to a PIDPlus controller. The tuning of the parameters is performed off-line by using genetic algorithms by considering a given data set of patients. Results: The effectiveness and robustness of the method is verified in simulation by implementing a Monte Carlo method to address the intra-patient and inter-patient variability. A comparison with a standard PID control structure shows that the event-based control system achieves a reduction of the total variation of the manipulated variable of 93% in the induction phase and of 95% in the maintenance phase. Conclusions: The use of event based automatic control in anesthesia yields a fast induction phase with bounded overshoot and an acceptable disturbance rejection. A comparison with a standard PID control structure shows that the technique effectively mimics the behavior of the anesthesiologist by providing a significant decrement of the total variation of the manipulated variable. |
| first_indexed | 2025-11-14T09:57:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-54189 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:57:47Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-541892018-07-02T00:39:36Z Event-Based control of depth of hypnosis in anesthesia Merigo, L. Beschi, M. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. Background and Objective: In this paper, we propose the use of an event-based control strategy for the closed-loop control of the depth of hypnosis in anesthesia by using propofol administration and the bispectral index as a controlled variable. Methods: A new event generator with high noise-filtering properties is employed in addition to a PIDPlus controller. The tuning of the parameters is performed off-line by using genetic algorithms by considering a given data set of patients. Results: The effectiveness and robustness of the method is verified in simulation by implementing a Monte Carlo method to address the intra-patient and inter-patient variability. A comparison with a standard PID control structure shows that the event-based control system achieves a reduction of the total variation of the manipulated variable of 93% in the induction phase and of 95% in the maintenance phase. Conclusions: The use of event based automatic control in anesthesia yields a fast induction phase with bounded overshoot and an acceptable disturbance rejection. A comparison with a standard PID control structure shows that the technique effectively mimics the behavior of the anesthesiologist by providing a significant decrement of the total variation of the manipulated variable. 2017 Journal Article http://hdl.handle.net/20.500.11937/54189 10.1016/j.cmpb.2017.06.007 Elsevier fulltext |
| spellingShingle | Merigo, L. Beschi, M. Padula, Fabrizio Latronico, N. Paltenghi, M. Visioli, A. Event-Based control of depth of hypnosis in anesthesia |
| title | Event-Based control of depth of hypnosis in anesthesia |
| title_full | Event-Based control of depth of hypnosis in anesthesia |
| title_fullStr | Event-Based control of depth of hypnosis in anesthesia |
| title_full_unstemmed | Event-Based control of depth of hypnosis in anesthesia |
| title_short | Event-Based control of depth of hypnosis in anesthesia |
| title_sort | event-based control of depth of hypnosis in anesthesia |
| url | http://hdl.handle.net/20.500.11937/54189 |