Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain
The development of a biocompatible dual ligand PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate drug delivery system to enhance delivery into the brain. Nanoparticulate formulations containing the drug rivastigmine had physicochemical characteristics ideal for targeting the brain and negligi...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2017
|
| Online Access: | http://hdl.handle.net/20.500.11937/54102 |
| _version_ | 1848759289867403264 |
|---|---|
| author | Huda, Naz Hasan |
| author_facet | Huda, Naz Hasan |
| author_sort | Huda, Naz Hasan |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The development of a biocompatible dual ligand PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate drug delivery system to enhance delivery into the brain. Nanoparticulate formulations containing the drug rivastigmine had physicochemical characteristics ideal for targeting the brain and negligible cytotoxicity. Cell uptake and transport were superior to the drug solution or nanoparticles without the ligand targeting technology. This dual ligand NP drug delivery system is a potential platform technology for brain delivery for a range of therapeutic outcomes. |
| first_indexed | 2025-11-14T09:57:31Z |
| format | Thesis |
| id | curtin-20.500.11937-54102 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:57:31Z |
| publishDate | 2017 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-541022022-06-03T06:50:57Z Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain Huda, Naz Hasan The development of a biocompatible dual ligand PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate drug delivery system to enhance delivery into the brain. Nanoparticulate formulations containing the drug rivastigmine had physicochemical characteristics ideal for targeting the brain and negligible cytotoxicity. Cell uptake and transport were superior to the drug solution or nanoparticles without the ligand targeting technology. This dual ligand NP drug delivery system is a potential platform technology for brain delivery for a range of therapeutic outcomes. 2017 Thesis http://hdl.handle.net/20.500.11937/54102 Curtin University fulltext |
| spellingShingle | Huda, Naz Hasan Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain |
| title | Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain |
| title_full | Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain |
| title_fullStr | Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain |
| title_full_unstemmed | Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain |
| title_short | Development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain |
| title_sort | development of a novel nanoparticulate carrier system for enhancement of bioactive molecule delivery into the brain |
| url | http://hdl.handle.net/20.500.11937/54102 |